Medicina

Heart failure is predominantly a disease of the elderly; aging of the population is contributing to an epidemic of heart failure. The epidemiology, pathophysiology, prognosis, clinical manifestations, diagnostic assessment, etiology, and role of echocardiography in the diagnostic assessment and etiology of heart failure are discussed. The treatment of heart failure in the elderly through the use of diuretics, inotropic drugs, neurohormonal antagonists, antiarrhythmic drugs, angioplasty, surgical therapy, cardiac resynchoronization therapy, exercise therapy, and use of implantable cardioverter-defibrillators are presented. All of the authors who have contributed to this book are nationally and internationally recognized experts in cardiovascular disease in the elderly who are dedicated to improving care for older persons with cardiovascular disease. Their many years of personal experience enable them to summarize and synthesize their respective topics with unique insights that are highly beneficial to the reader.

Tools, techniques, and progress in cancer biomarkers discovery The completion of a number of gene sequencing projects, recent advances in genomic and proteomic technologies, and the availability of powerful bioinformatics tools have led to promising new avenues and approaches in the search for cancer biomarkers. This book provides a comprehensive overview of current methodologies and technologies. It discusses biomarker discovery as a whole, rather than focusing on one specific marker or cancer. With information on both existing and potential biomarkers, Cancer Biomarkers: Analytical Techniques for Discovery: Provides insights into the current technological platforms for biomarker discovery, including mass spectrometry combined with multidimensional chromatography, DIGE, and various chip technologies Includes a detailed discussion of protein networks and protein phosphorylation in cancer Details the use of imaging mass spectrometry, laser capture microdissection, serial analysis of gene expression, enzyme-linked immunosorbent assays, protein microarrays, antibody-based microarrays, and bioinformatics Covers the emerging role of surface-enhanced laser desorption ionization (SELDI) and various tagging and labeling strategies Discusses related regulatory and ethical issues With a wealth of information that can be applied to a broad spectrum of biomarker research projects, this is a core reference for biomarker researchers, scientists working in proteomics and bioinformatics, pharmaceutical scientists, oncologists, biochemists, biologists, and chemists.

Since the first edition of this very successful book was written to synthesise and review the enormous body of work covering falls in older people, there has been an even greater wealth of informative and promising studies designed to increase our understanding of risk factors and prevention strategies. This second edition, first published in 2007, is written in three parts: epidemiology, strategies for prevention, and future research directions. New material includes recent studies covering: balance studies using tripping, slipping and stepping paradigms; sensitivity and depth perception visual risk factors; neurophysiological research on automatic or reflex balance activities; and the roles of syncope, vitamin D, cataract surgery, health and safety education, and exercise programs. This edition will be an invaluable update for clinicians, physiotherapists, occupational therapists, nurses, researchers, and all those working in community, hospital and residential or rehabilitation aged care settings.

This practical text presents a wealth of fresh ideas and techniques for strengthening counseling skills to face real-world issues in nutrition therapy. It offers students and practitioners advice on ways to increase referrals, decrease no-shows, and overcome common barriers to effective counseling. The Third Edition also explores strategies for counseling patients with AIDS, diabetes, and other chronic diseases, for group therapy, for teaching developmental skills, and for end-of-life counseling. This edition has a new reader-friendly design and layout. New learning activities - including case studies and critical thinking exercises - encourage students to apply what they have learned to common situations in clinical practice.

The definitive work on occupational therapy for physical dysfunction returns in its Sixth Edition, with reputable co-editors and clinical, academic, and consumer contributors. This text provides a current and well-rounded view of the field- from theoretical rationale to evaluation, treatment, and follow-up. Through the Occupational Functioning Model (OFM), the Sixth Edition continues to emphasize the conceptual foundation and scientific basis for practice, including evidence to support the selection of appropriate assessments and interventions. NEW TO THIS EDITION: Student DVD with video clips demonstrating range of motion, manual muscle testing, construction of hand splints, and transferring patients Evidence Tables summarize the evidence behind key topics and cover Intervention, Participants, Dosage, Type of Best Evidence, Level of Evidence, Benefit, Statistical Probability, and Reference Assessment Tables summarize key assessment tools and cover Instrument and Reference, Description, Time to Administer, Validity, Reliability, Sensitivity, and Strengths and Weaknesses.

This handbook is a practical and comprehensive guide to the diagnosis and management of osteoporosis. The book covers all aspects of osteoporosis, from pathophysiology to diagnostic tests and therapies, and includes actual case studies with teaching points. Separate chapters focus on vitamin D deficiency and workup and recognition of secondary causes of bone loss. Coverage of treatment includes tailoring therapy to individual patients, determining the success of therapy, what to do when therapy fails, and future therapeutic options. The authors review the latest evidence and provide annotated references so readers can examine the methodology, results, and conclusions of the studies.