Hodder Arnold

Extracorporeal circulation has become firmly established as an invaluable and routine adjunct to cardiac and vascular surgery. Since its introduction in 1953, the technique has evolved rapidly with advancing technology leading to improvements in and simplification of the equipment involved. Developments in the understanding and application of basic science have also had a huge impact as our understanding of the complex anatomy, biochemistry, pharmacology and pathophysiology of the heart continues to grow. It is these advances in both technology and science that form the basis of this fourth edition of "Techniques in Extracorporeal Circulation". The book continues to provide a comprehensive overview of the field, covering both established techniques for those new to the field of extracorporeal circulation, and current and future developments. It attempts to answer some of the innumerable practical problems associated with the routine use of artificial circulation and oxygenation, and hopes to stimulate thought and debate among its readers regarding more complex or controversial issues. Topics new to the fourth edition include robotic surgery and off-pump surgery, while other chapters have been thoroughly revised and updated to take into account developments and changes in the field. With its multidisciplinary approach, the book will remain an essential reference for all health care professionals working in the cardiac surgical operating room, in particular cardiothoracic surgeons, anaesthetists and perfusionists.

During the past decade there has been an enormous increase in knowledge of multiple myeloma and related disorders, reflected in the publication of more than 5000 articles on the subject in scientific journals. Much of this has come about as new technologies have made it possible to refine studies on chromosomes and genes and to gain information about gene expression. It is therefore highly appropriate that this new comprehensive reference should appear at this time. The book covers the whole field of multiple myeloma, and also related diseases such as Waldemstrom's macroglobulinaemia, and incorporates both the basic science underlying the diseases and their clinical management. Each chapter has been written to 'stand alone', allowing the reader to dip into a particular subject and find information quickly without the need to browse through multiple chapters. In addition to the developments described above, all of which are considered here, many other approaches to targeted therapy are reviewed.

Lung disease is a major indication for the admittance of the neonate to a specialist intensive care unit, and is a particularly common complication in the pre-term baby where the lungs are insufficiently developed at birth and easily damaged by early treatments. As a consequence, this is an area of intensive international research activity. In this comprehensive update of the well-received first edition, leading researchers from all over the world have been invited to contribute in their specialist areas. The book continues to provide detailed coverage of the pathogenesis, clinical and laboratory features and management of lung disorders in the neonate, with increased emphasis on the underlying immunology and major additions to the sections on respiratory support, chronic lung disease and abnormalities in lung growth and development to reflect the changes that have occurred in these areas since the previous edition appeared in 1995. Providing an unrivaled up-to-date statement on the problems that are faced in the neonatal intensive care unit on a daily basis, this is an invaluable addition to the bookshelves of neonatologists and other personnel involved in the care of critically ill babies.

This highly regarded dermatology textbook with an international reputation has been thoroughly updated and refined throughout in this 17th edition. Adopting a more concise and 'user-friendly' style, and with increased emphasis on basic science, diagnostic procedures and clinical management, it remains an invaluable reference for house officers, SHOs, GPs and dermatology trainees, and for senior medical students looking for an introduction to the subject. With its reader friendly approach and over 350 superb clinical photographs and explanatory colour diagrams, "Roxburgh's Common Skin Disorders" remains a key learning resource in the field of dermatology to be referred to often during study and in the clinical setting.

This fully updated revision of the well-received first edition continues to provide a clear, comprehensive and up-to-date account of the role of lipid management in the prevention of coronary heart disease. Appropriate for the clinician managing lipid problems in either the primary or secondary care setting, the well-respected author team consider all aspects of screening, diagnosis and risk assessment, and management. The science underlying lipid metabolism is put into context for the practising physician, including recent developments in inflammation, plaque biology and the transition to serious events. Risk factor modification, including lifestyle change and cholesterol lowering by diet and medication are discussed fully. Landmark clinical trials, and the messages that can be drawn from them, are highlighted throughout. The practical focus is maintained through the consideration of specific patient groups demonstrating particular clinical importance, management difficulties or highlighting areas of current controversy. With a balanced, readable style and clear explanatory illustrations, this second edition provides invaluable advice for primary care and specialist clinicians, whether in training or in practice, in the management of lipid disorders and the prevention of cardiovascular events.

This practical pocket reference provides advice on management of acute cardiac problems, a major component of all emergency medical admissions. Advocating an evidence-based approach to clinical practice, the book gives detailed guidelines for day-to-day use in patient care in a variety of hospital settings - from admission in A&E through intensive therapy in the CCU to management on the cardiac or medical ward. The concise presentation is designed to allow easy access to relevant material.

The new fourth edition of this highly successful textbook covers the entire subject of neurophysiology from the conduction of nerve impulses to the higher functions of the brain. Particular emphasis is placed on principles and functional concepts. The book is accompanied by a CD containing not only an upgraded version of the highly acclaimed Neurolab interactive simulations, but an atlas of neuroanatomy, animated diagrams of brain development, MCQs with timings and explained answers, a review of neuro websites on neuroscience with links, and moving footage of the neurological examination and the clinical signs of the major neurological conditions. With more functional anatomy and clinical cases, this new edition presents an integrated textbook of neurology/neuroscience for medical students, physiology students, neuroscience students, and bioscience students taking physiology and neuroscience modules. It includes free CD with innovative, interactive simulations and other material, including the full, searchable text.

A complete revision of this successful pocketbook, the fourteenth edition of A Paediatric Vade-Mecum provides the junior doctor and trainee grade paediatrician with invaluable information on the diagnosis and management of illness in children, and with practical evidence-based advice for the safe and effective management of the sick child. Retaining the easy-to-digest style that has made previous editions so popular, the content has been restructed into five major sections: acute paediatric problems, outpatient paediatrics, formulary, normal values and glossary of terms, with entries in sections 1 and 2 organised alphabetically for ease of reference. Pre-registration house officers, SHOs and SpRs in Paediatrics, and GPs in training should not be without a personal copy.

This comprehensive account of the biological basis and clinical management of childhood asthma and other wheezing disorders brings together all the aspects necessary for full understanding by the trainee or practising respiratory physician, paediatrician, or specialist nurse of therapist. The text reviews the nature of childhood asthma, its developmental and biological origins and its impact both for the individual and for society. In each section the scientific background is brought together with comprehensive clinical information, reviewed where possible with an evidence base in mind, providing the reader with informed guidance to best practice. Thoroughly revised and updated throughout, this second edition reflects the significant developments that have occurred in the field during recent years. Advances in medical genetics are discussed, new techniques for investigation of inflammatory processes and for the evaluation of the impact of childhood asthma are described fully, additional information on the aetiology of this condition is provided and the pharmacology section includes a description of the leukotriene receptor agonists, the first novel drug therapy to emerge for 20 years. An entirely new section devoted to 'asthma around the world' including personal perspectives from clinicians from Japan, Africa, Latin America, and elsewhere has also been added. The book continues to place childhood asthma in a wider social context, with sections on teachning and training for health professionals outside the hospital setting and the delivery of care in the community. It remains essential reading for all paediatricians and respiratory physicians in training and in practice, and will also provide invaluable reference material for other health care professionals caring for babies, children and adolescents with asthma and wheezing disorders.

This is a practical manual that describes the assessment and treatment of conditions encountered in the emergency department. Highly illustrated, it emphasises the problem-oriented approach central to modern practice. Structured to serve as a quick reference on a wide range of medical and surgical emergencies, summary boxes, key points and practice tips feature throughout. Whilst making it highly accessible, the editors have also ensured that this book provides the trainee with the detailed information that they require.

Making Sense of Critical Appraisal provides all the necessary information on how to read and understand medical research publications critically and to decide whether the contents of such publications are clinically useful in the care of patients. Illustrated throughout with medically relevant examples, this text covers all aspects of study design and clinical audit to give a clear framework for critical reading.

Clinical Pain Management is a major new clinical reference work. Comprised of four volumes - Acute Pain, Chronic Pain, Cancer Pain and Practical Applications and Procedures - it is a comprehensive textbook for trainee and practising specialists in pain management and related areas, presenting these individuals with all they need to know to provide a successful pain management service. The set includes three clinical volumes that deal respectively with all aspects of acute, chronic and cancer pain - from the basic mechanisms underlying the development of pain, to the various treatments that can be applied in different clinical situations. A fourth volume, Practical Applications and Procedures, complements these three by providing helpful advice on practical aspects of clinical management and research, including protocols and established clinical guidelines: in effect, a 'ready-reference manual' for the busy clinician.

This concise, but comprehensive textbook sets out all the essentials of the science and clinical application of radiobiology for those seeking accreditation in radiation oncology. The fully updated 3rd edition continues to discuss the basis of radiation therapy and presents the principles and significant scientific developments that underlie current attempts to improve the radiotherapeutic management of all cancers. New topics in the 3rd edition include chapters on volume effects in normal tissues and the L-Q approach in clinical practice, with major revisions to sections on cell proliferation, radiation cytogenetics, radiotherapy-related morbidity, hyperfractionation and individualisation of radiotherapy. The book continues to provide invaluable advice for trainee and practising radiation oncologists from a team of internationally respected contributors and draws on the considerable experience of the Editor, gained during his time as Course Director of the annual ESTRO course in Basic Clinical Radiobiology.

This book is an authoritative, comprehensive and up-to-date review of the pathophysiological basis, diagnosis and management of disorders of the blood vessels that supply the gastrointestinal tract and major solid abdominal organs. Impaired blood supply of the viscera can have disastrous consequences such as multiple organ failure. Previously under-diagnosed, these conditions are becoming recognized as important contributors to post-operative morbidity and mortality. Written by leading international figures, "Diseases of the Visceral Circulation" analyses in depth these conditions and their management by conservative, interventional radiological and surgical therapies. With this subject rapidly gaining momentum as both a research area and a topic of significant clinical importance, the book provides a timely and balanced discussion of the field.

This internationally recognized source book is now referred to in court cases around the world. It deals with all aspects of scientific estimation of time since death, emphasising the practical application to the work of the forensic pathologist. The new edition includes completely rewritten chapters on lividity and thanatochemistry, changes in infants and children after death and gastric contents. Clinical cases have been added to illustrate the points made. The latest research has been taken into account on key issues such as rigor mortis.

"Concise Histology" is the successor to Bloom and Fawcett's "Textbook of Histology", taking the best features of that classic textbook and presenting them concisely for today's courses that focus on core information and skills. Now in its second edition, "Concise Histology" presents the essential elements of the body at the cellular, tissue and systems levels, fully illustrated in colour throughout. Accompanying the text is a supplementary CD containing over 500 photograph-based Questions and Answers for practice and self-assessment.

Previous editions of this book have proved indispensable for trainee surgeons preparing for the MRCS and AFRCS examinations. This extensively revised new edition is presented in a compelling new style and in a larger format. Beginning with a 'route-map' showing 'how to use this book', the text offers concise accounts of the core topics in pathology required of surgeons in training. There is particular emphasis on tissue pathology but full account is taken of relevant aspects of microbiology, haematology, immunology and clinical chemistry. Tables of normal laboratory values are included. Each major disorder is examined from the point of view of Cause, Structure, and Behaviour. Genetics, molecular biology and imaging receive balanced attention as do transfusion, telepathology and audit. The use of computers is outlined and suggestions given on access to Internet sources for learning purposes. The needs of trainees in countries outside Europe have been considered carefully. Illustrations have been selected to provide a clear, pictorial account of complex points. The inclusion of biographies of surgical pioneers adds interest and enables candidates to put their knowledge into context. A special feature is a series of marginal 'signposts' in the form 'Now Read' that take candidates to interrelated topics quickly and easily. There is extensive cross-referencing and a comprehensive index.

This introductory handbook of colposcopy, now in its second edition, is a concise, up-to-date guide to the fundamentals of modern colposcopic practice. The editors, all highly respected in the field, have brought together a team of renowned contributors from a variety of disciplines to give a comprehensive, well-balanced view. Based loosely upon the syllabus of the course run by the British Society of Colposcopy and Cervical Pathology, it gives the trainee colposcopist a sound grounding in the basic principles without overloading them with unnecessary 'weighty' information. For this second, the content has been revised throughout to reflect the changes in the field. In particular, cervical cytology has been thoroughly updated to encompass revised developments in automated screening, indications for referral have been rewritten with regard to the new National Guidelines, there have been significant changes to the sections on recording information, the role of HPV and patient counselling and an entirely new chapter on training, accreditation and certification has been introduced. The MCQs, a popular feature in the previous edition, have been retained and updated, and case histories have been included as an additional self-assessment tool. Designed to complement and reinforce practical experience gained in the clinic, "Handbook of Colposcopy 2E" remains essential reading for trainee and newly qualified colposcopists, nurse assistants and general gynaecologists, and will also be of interest to genitourinary physians, and to trainee histopathologists, cytologists and cytoscreeners.

In this third edition, Knight's Forensic Pathology continues to be the definitive international postgraduate textbook for forensic pathologists, covering all aspects of the medico-legal autopsy, including the cause and time of death, interpretation of wounds and every other facet of the investigation of a fatality. The emphasis is on the practical application of knowledge and research findings, and the new edition continues the often praised traditions of clarity and succinct presentation. This book will be an essential text for all pathologists in training, and remains a standard text to those in practice.