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Tutti i libri editi da Cambridge - Pagina 25
Biomarkers of Disease
An Evidence-Based Approach
Andrew Trull
,
Atholl Johnston
e altri
editore: Cambridge
pagine: 518
This publication takes a critical, evidence-based look at the efficacy of diagnostic tests which are increasingly being used to evaluate organ damage and dysfunction. The use of biomarkers is growing, with a steady stream of products being brought out by the pharmaceutical industry. Some of these assist in diagnosis, others provide a means of monitoring the state of progression of disease and the effectiveness of therapeutic options. However, in many cases the evidence which supports the use of these methods as opposed to traditional biochemical tests has not yet been demonstrated, and it is intended that this volume will help clarify the strengths and weaknesses of using these biomarkers across a wide range of applications and in the various organs of the body. This approach will provide pathologists, clinical biochemists and medical laboratory scientists with an invaluable overview of the diverse applications of biomarkers in medicine.
Platelets in Thrombotic and Non-thrombotic Disorders
Pathophysiology, Pharmacology and Therapeutics
Clive P. Page
,
Jos Vermylen
e altri
editore: Cambridge
pagine: 1124
Platelets have become an important research target for clinicians and basic scientists in a range of medical disciplines. This book reviews current science and applications in fields including thrombosis and hemostasis, signal transduction, and non-thrombotic conditions such as inflammation, allergy and tumor metastasis. It is a detailed, up-to-date, highly referenced text for clinical scientists and physicians, including recent developments in this rapidly expanding field. More than a scientific resource, this is also an authoritative reference and guide to the diagnosis and therapeutics of diseases involving platelets. Chapters are devised to provide a critical review of the most clinically relevant aspects of the subject. It will be an essential reference for biomedical scientists and clinicians in hematology, vascular medicine, cardiology, thrombosis and related disciplines.
Practical Child and Adolescent Psychopharmacology
Stanley P. Kutcher
editore: Cambridge
pagine: 484
The field of child and adolescent psychopharmacology is rapidly growing, but psychopharmacological treatments for children cannot be straightforwardly extrapolated from adult studies, which presents clinicians with assessment and prescribing challenges. This important book synthesises research findings about drug treatment of a broad range of psychiatric disorders in children, including attention-deficit hyperactivity disorder, obsessive-compulsive disorder, major depression, schizophrenia, bipolar mania, aggression in pervasive developmental disorder, Tourette's syndrome and substance abuse. They examine the issues of tolerability and efficacy, and appropriate use, within a social and developmental context. For each disorder, pharmacotherapy is discussed in the wider context of neurobiology, etiology, diagnosis and treatment. This will be essential reading for all mental health professionals to inform practice and improve patient outcomes.
Hepatitis C Virus
From Laboratory to Clinic
Mark A. Feitelson
editore: Cambridge
pagine: 270
Hepatitis C infects 170 million people worldwide, and has been labelled the 'silent epidemic' as a result of its concealed attack on the liver. This multidisciplinary overview covers basic concepts related to the discovery of the virus, development of serological and nucleic acid tests to detect infection, the structure of the virus genome, generation of virus gene products, and proposed replication scheme. It then goes on to introduce the epidemiology, transmission, pathogenesis of infection, the development of hepatocellular carcinoma associated with chronic virus infection, and current strategies for treatment. The book then discusses advances in cell culture systems, animal models of infection, and emerging treatments and vaccine development. Through its coverage of basic science, clinical consequences, and methods of research, this integrated and accessible account will be of immense value to biomedical scientists and clinicians alike, and a useful introduction for all those studying the virus and its effects.
Drugs and Addictive Behaviour
A Guide to Treatment
Hamid Ghodse
editore: Cambridge
pagine: 520
In this completely revised and updated third edition of his highly successful book, Hamid Ghodse presents a comprehensive overview of substance misuse and dependence. There is a particular emphasis on practical, evidence-based approaches to the assessment and management of a wide range of drug-related problems in a variety of clinical settings, and he has written an entirely new chapter on alcohol abuse. He defines all the terms, and describes the effects of substance misuse on a patient's life. Epidemiology, and international prevention and drug control policies are covered to address the global nature of the problem, and the appendix provides a series of clinical intervention tools, among them a Substance Misuse Assessment Questionnaire. This will be essential reading for all clinicians and other professionals dealing with addiction, from counsellors and social workers to policy makers.
The Vegetative State
Medical Facts, Ethical and Legal Dilemmas
Bryan Jennett
editore: Cambridge
pagine: 242
The strange and harrowing sight of a person being awake but unaware with no evidence of a working mind - the characteristics of the vegetative state - provokes intense debate and raises profound questions for health professionals, ethicists, philosophers and lawyers. This unique account by an unrivalled expert in the field, who himself collaborated in coining the term 'persistent vegetative state', surveys the medical, ethical and legal issues that surround this controversial topic. The medical definition and criteria for diagnosis are discussed, as are its frequency and causes, and possible outcomes. Ethical arguments discussed include the conflict between sanctity of life and respect for the autonomy and best interests of the victim, and between killing and letting die. Legal issues are explored with details of landmark court cases from the USA, Britain and elsewhere. This well-informed and carefully constructed account will be a benchmark for medical specialists, ethicists, lawyers and philosophers.
Introduction to Functional Magnetic Resonance Imaging
Principles and Techniques
R. B. Buxton
editore: Cambridge
pagine: 536
Functional Magnetic Resonance Imaging (fMRI) is now a standard tool for mapping activation patterns in the human brain. This highly interdisciplinary field involves neuroscientists and physicists as well as clinicians, and the range, flexibility and sophistication of the techniques being used are increasing rapidly. In this book, Richard Buxton, a leading authority on fMRI, provides an invaluable introduction to how fMRI works, from basic principles and the underlying physics and physiology, to newer techniques such as arterial spin labeling and diffusion tensor imaging. The book also includes discussion of how fMRI relates to other imaging techniques (such as Positron Emission Tomography, or PET) and a guide to the statistical analysis of fMRI data. This book will be useful both to the experienced researcher using fMRI, and the clinician or researcher with no previous knowledge of the technology.
DNA microarrays and gene expression
From experiments to data analysis and modeling
Baldi, P. , Hatfield, G. W.
editore: Cambridge
pagine: 213
The imitative mind
Development, evolution and brain bases.Cambridge Studies in cognitive and perceptual development
Meltzoff, A. N. , Prinz, W.
editore: Cambridge
pagine: 352
The Cerebellum and its Disorders
Mario-Ubaldo Manto , Massimo Pandolfo
editore: Cambridge
pagine: 612
Recent years have seen major advances in the understanding of motor and non-motor operations of the cerebellum, including its role in cognition, and important discoveries in the genetics of the cerebellar ataxias. This is a comprehensive text on the cerebellum and its disorders. It ranges from embryology and basic neuroanatomy to a thorough survey of the sporadic and hereditary disorders of the cerebellum. Models of cerebellar function and clinical-pathophysiological correlations are thoroughly covered, and there is an extensive and authoritative review of recent advances in the genetics of cerebellar diseases. The chapters are written by the leading international authorities on the cerebellum, including many of those who made fundamental discoveries in the field. The first comprehensive text on the cerebellum to be published for many years, this book will be essential reading for a wide range of basic and clinical neuroscientists, neurologists and others studying or treating cerebellar disorders.
Handbook of Women's Health
An Evidence-Based Approach
Jo Ann Rosenfeld
editore: Cambridge
pagine: 628
This practical handbook provides a clear and comprehensive evidence-based primary-care guide to the care of women in ambulatory practice, intended for general and family practitioners, nurses, physicians' assistants and all those who practise primary care of women. It emphasizes preventive care and well-woman care throughout the lifecycle of a woman, including sexuality, contraception, medical care in pregnancy, psychological and important medical concerns. It stresses the strength of evidence underlying common practices of care of women. * It recognises and pays heed to the cultural, social and psychological differences that impact on women's health * It conveys a consistently positive message in terms of seeking solutions to women's health care problems and emphasizes preventive health care * It provides insightful tips and checklists to highlight women's common health problems and effective evidence-based treatment * Suitable for health care workers of all levels and specialties who practise primary care of women
Cambridge Guide to Infertility Management and Assisted Reproduction
Godwin I. Meniru
editore: Cambridge
pagine: 292
This well-illustrated publication provides concise yet comprehensive practical information on the modern-day approach to the diagnosis and treatment of infertility. It starts from basic principles of reproductive physiology, before moving on to the medical causes of infertility, and then describes and explains the full armory of techniques from IVF to ICSI and even newer technologies used to treat infertility in all its manifestations. The aim throughout is to explain issues clearly, simply and directly in such a way that will be understood by doctors, scientists and nurses alike. By combining basic science and medical aspects, along with 'how it is done' descriptions of techniques and medical interventions, this book offers an unsurpassed introductory account of this fast moving area and is highly suitable for the full range of personnel involved in looking after the infertile patient, including trainees in medicine and nursing, clinical embryologists, andrologists, ultrasonographers and counsellors.
Toxoplasmosis
A Comprehensive Clinical Guide
David H. M. Joynson , Tim G. Wreghitt
editore: Cambridge
pagine: 410
This authoritative and comprehensive account looks at the re-emergence of toxoplasmosis as a significant and potentially fatal infection. A team of acknowledged international experts review the latest diagnostic techniques, and the management of infection in pregnant women, neonates, the eye, transplant and other immunosuppressed patients and those with AIDS. The contentious issue of the role of screening during pregnancy and in the new-born is covered in depth. The introductory chapters on biology, immunology and epidemiology of the infection provide essential background to understanding the clinical disease. The full range of treatment strategies are presented in an easily accessible form. The natural history and life cycle of the causative organism, Toxoplasma gondii, provide a fascinating insight into one of the most successful parasites on earth. Although the burden of this disease varies greatly from country to country, it remains a global public health problem which affects about one billion individuals.
Traumatic Pasts
History, Psychiatry, and Trauma in the Modern Age, 1870-1930
Charles Rosenberg
,
Colin Jones
e altri
editore: Cambridge
pagine: 336
Traumatic Pasts, originally published in 2001, offers a variety of perspectives on mental trauma in war, medicine, culture and society in modern European and American history. Its primary goals are: to provide a generous sampling of the best of the historical scholarship about trauma; to indicate the empirical, analytical and methodological scope of this work; and to present some of the conceptual and methodological issues inherent in writing about the subject. The book operates on the premise that the historical humanities have something crucially important to say about trauma; its essays may be read, in part, as attempts to introduce a deep historical dimension into ongoing debates and controversies. However, it is important to stress that these essays are not simply addressed the concerns; rather, they reflect a shared conviction that trauma opens up fresh perspectives in the study of social and cultural history.
Investigating Neurological Disease
Epidemiology for Clinical Neurology
A. Hofman , Richard Mayeux
editore: Cambridge
pagine: 326
In the clinical neurosciences, decision-making becomes ever more complicated because of rapidly emerging new diagnostic tests and treatments and increasing demands from patients to participate in their management. This concise but wide-ranging handbook reviews the epidemiology of neurological disease and the treatment and prognosis of all major diseases of the nervous system. Part one offers essential guidance for clinicians to quantitative methods in research, including genetic epidemiology, decision analysis, meta-analysis, outcomes research and survival analysis, and thus provides a good understanding of the evidence underlying clinical management. The second part is devoted to individual neurological diseases, covering etiology, diagnosis, prognosis, interventions, and implications for clinical practice. With contributions from leading international authorities, this book is an invaluable guide to clinical decision-making for neurologists and others involved in the management of neurological disease.
Oculomotor Systems and Perception
Sheldon M. Ebenholz
editore: Cambridge
pagine: 236
This 2001 text was the first to emphasize the role of oculomotor systems in perception. Oculomotor systems that regulate eye movements play an important role in accounting for certain qualities of visual experience. They are implicated in a wide array of perceptual topics, from apparent size, depth, and distance, to apparent slant and vertical orientation. The text begins with a brief introduction to the basic characteristics of such oculomotor systems as those controlling vergence, pursuit, the vestibulo-ocular response, and saccadic eye movements. Also introduced are fundamental concepts in physiological optics. Next explored are mechanisms of perception, with a particular focus on eye movements, and the remarkably diverse implications of oculomotor research, which extend to motion sickness and life in space orbit. Insights into dysfunctional vision are also offered. This book complements standard texts on visual perception, yet may be read independently by those with a modest background in vision science.
Homocysteine in Health and Disease
Donald W. Jacobsen , Ralph Carmel
editore: Cambridge
pagine: 526
High levels of homocysteine have been identified as a very important risk factor in cardiovascular disease. Homocysteine-related abnormalities are also thought to contribute to birth defects and dementia, and there are many common acquired diseases, drugs and genetic disorders which adversely affect the metabolism of homocysteine. In this 2001 book a multidisciplinary team of experts in the field give a clear analysis of the biochemistry, genetics, epidemiology, clinical settings, causes, impact and treatment of homocysteine disorders. This is an unusually comprehensive account of the broad range of medical, nutritional and methodological implications of homocysteine in health and disease.
Fetal Growth and Development
Alan D. Bocking , Richard Harding
editore: Cambridge
pagine: 294
The fetus occupies a critical phase during human development, when the body systems that will support us throughout our lives begin to face up to the challenge of life outside the womb. Whilst the fetus can demonstrate a remarkably robust response to challenges in the uterus, it is also an exquisitely sensitive phase of development. It is now well recognized that disturbances to the materno-fetal environment can influence and even undermine our state of health well into adulthood. This exciting new publication provides a valuable insight into fetal growth and development across all the main body systems, and examines the influence of the materno-fetal environment on adult-onset diseases. Additional chapters on the embryo, the placenta and parturition will insure that this is a fully self-contained introduction. Written by world-renowned experts from leading centres of excellence, this account will be an invaluable introduction for students of medicine, reproductive biology and human biology.
The Cambridge Medical Ethics Workbook
Case Studies, Commentaries and Activities
Donna Dickenson , Michael Parker
editore: Cambridge
pagine: 376
This is a practical, versatile, case-based introduction to bioethics for anyone who is interested in the ethical issues raised by modern medicine. It is designed to be used both for individual reference and as a set text in group teaching or open learning environments. The workbook is structured around a variety of guided activities designed to introduce and examine the major ethical questions. The activities are clustered around actual cases (provided by an international team of health care professionals), commentaries (from clinicians, ethicists and lawyers), and short papers. The range of problems covered includes ethical issues raised by new reproductive and genetic technologies, the rights of vulnerable groups, and allocation of scarce medical resources. The workbook will be invaluable to practitioners, medical and nursing students, and anyone who needs to develop skills in ethical analysis for clinical practice or research.
Upper Motor Neurone Syndrome and Spasticity
Clinical Management and Neurophysiology
Garth R. Johnson , Michael P. Barnes
editore: Cambridge
pagine: 328
This is a practical reference and guide for physicians, surgeons, therapists, orthotists, bioengineers and other health professionals involved in the management of a disabled individual with upper motor neurone syndrome and spasticity. It is a thorough review, covering all aspects of management from physiotherapy, seating, and orthoses to the use of drugs. It examines the neurophysiology of spasticity, measurement of outcome, and the newer treatment techniques, such as phenol and alcohol nerve blocks and botulinum toxin injections. More invasive procedures, including intrathecal baclofen and surgical intervention for more complex and severe spasticity, are covered in detail, and the final chapter looks closely at the management of spasticity in children.
