Disorders of neuronal migration can cause learning disability, autism, and epilepsy. Many are genetically determined and need precise diagnosis to provide genetic counselling. This book will help the clinician to acquire insight as well as proficiency in diagnosis. Individual chapters describe subgroups including lissencephalies, subependymal heterotopia, non-lissencephalic cortical dysplasias, anomalies of the corpus callosum, hemimegalencephaly, schizencephaly, polymicrogyria and multisystem disorders with impaired migration such as chromosomal and metabolic syndromes. Neuroradiological and genetic data are provided with the respective chapters. Although the book is intended for clinical practice, it provides core information for all interested in this important biological process.
Indice testuale
Introduction, Peter G. Barth Morphogenesis of the human cerebral cortex, V. S. Caviness Jr, T. Takahashi, R. S. Nowakowski and Robert Wood Lissencephaly: the clinical and molecular genetic basis of diffuse malformations of neuronal migration, William B. Dobyns and Richard J. Leventer Non-lissencephalic cortical dysplasias, Ruben I. Kuzniecky and Frederick Andermann Periventricular gray matter heterotopia: a heterogenous group of malformations of cortical development, Richard J. Leventer and William B. Dobyns Anomalies of the Corpus Callosum and cortical malformations, A. James Barkovich Hemimegalencephaly, Laura Flores-Sarnat Index
