This is a modern text that combines the fundamentals of methodology with key elements of interpretation. This book blends business and management issues, analytical principles, and clinical material for practicing pathologists, residents, fellows, and laboratorians. The text is organized into three major sections: laboratory management, instrumentation and methods, and analysis and clinical correlation. The first section addresses issues essential for running a profitable laboratory; modern techniques and instrumentation are examined in the second section; and the analysis and clinical correlation section provides the reader with numerous diagnostic algorithms that illustrate common work-ups and problems. In addition, case studies selectively illuminate specific clinical issues.
SECTION 1: LABORATORY MANAGEMENT Overview of Laboratory Management Accreditation and Regulation in the Clinical Laboratory Human Resources Management Laboratory Safety:An Overview The Laboratory Manager: Role in Compliance, Organizational Structure, and Financial Management Budget Management and Benchmarking Cost Accounting In the Clinical Laboratory Quality Control / Quality Assurance Diagnostic Accuracy of Laboratory Tests and the Establishment of Reference Ranges Method Evaluation and Technology Assessment Operations Analysis, Reengineering and Process Improvement Reimbursement for Laboratory Services Point-of-Care Testing Specimen Transport, Logistics and Processing Integrated Automation in the Chemistry Laboratory Development of Laboratory Instrument Platforms Assay Development and the Role of the FDA Role of Laboratories in Integrated Delivery Networks The Commercial Reference Laboratory Management of Test Utilization Acute Care and STAT Laboratory Testing The Role of the Diagnostics Industry in the Clinical Chemistry Laboratory SECTION 2: INSTRUMENTATION AND METHODS General Laboratory Techniques, Units of Measurement, and a Table of Representative Normal Reference Values Contemporary Instruments of the Chemistry Laboratory Photometric Methods, Fluorometry, Atomic Absorption/Nephelometry Turbidometry Mass Spectrometry An Introduction to Clinical Laboratory Immunodiagnostics: A Perspective from the Diagnostics Industry Immunoassay and Immunoassay Analyzers: A Perspective from the Clinical Laboratory Chromatography and Capillary Electrophoresis Principles and Practical Consideration Electrochemistry Electrophoresis Measurement of Osmolality and Specific Gravity Molecular Diagnostics: Methods and Applications Clinical Enzymology Radioimmunoassay SECTION 3: ANALYSIS AND CLINICAL CORRELATION The Plasma Proteins Glucose and Carbohydrates Lipids, Lipoproteins, and Cardiovascular Risk Assessment Laboratory Diagnosis of Disorders of the Thyroid Gland Laboratory Evaluation of Pituitary Disorders, Adrenal Cortex and Medulla, and Selected Neuroendocrine Tumors Reproductive Endocrinology Acid-Base and Electrolyte Disorders Respiration and the Evaluation of Hypoxemia, Hypercapnia, and Related Disorders Cardiac Markers Renal Function and Nitrogen Metabolites Calcium, Magnesium, and Phosphate Evaluation of Hepatic Function and Disorders of the Liver Inborn Errors of Metabolism Toxicology and Therapeutic Drug Monitoring Therapeutic Drug Monitoring Trace Elements, Vitamins, and Nutrition Iron and Porphyrins Human Chorionic Gonadrotropin and Clinical Laboratory Testing in the Diagnosis and Management of Pregnancy Clinical Chemistry of Urine, Pleural Effusions, and Ascites Tumor Markers Disorders of the Nervous System: Cerebrospinal Fluid Disorders of Coagulation Disorders of Bone Chemistry and Clinical Correlations Laboratory Evaluation of Pancreatic Disorders, Malabsorption, and Diseases of the Gastrointestinal System INDE