Molecular Basis of Cardiovascular Disease

I. General Principles of Molecular Cardiology Chapter 1: Biotechnology and Cardiovascular Medicine: Recombinant Protein Therapy (Hiroshi Ashikaga, Kenneth R. Chien) Chapter 2: Human Genome Project and Cardiovascular Disease Genes (CC Liew, Victor J. Dzau) Chapter 3: Model Organisms for Cardiac Disease Gene Discovery (Calum A. Macrae, Mark C. Fishman) Chapter 4: Generation and Cloning of Genetically Modified Animals (Leon J. DeWindt, Pieter A. Doevendans, Kenneth R. Chien) Chapter 5: Mouse Models of Human Cardiovascular Disease (Geir Christensen, Ju Chen, John Ross, Jr., Kenneth Chien) Chapter 6: Towards Stem Cell Therapy (Pieter A. Doevendans, Christine Mummery, Kenneth Chien) Chapter 7: Cardiovascular Signaling Pathways (Susan F. Steinberg, Michael Karin, Joan Heller Brown) Chapter 8: Genetic Approaches to Cardiovascular Disease (Carl J. Vaughan, Craig T. Basson) Chapter 9: Gene Transfer Approaches for Cardiovascular Disease (Elizabeth Nabel) II. Cardiac Development and Congenital Heart Disease Chapter 10: Cardiac Development and Congenital Heart Disease (Deepak Srivastava, Eric N. Olson) Chapter 11: Development of Pacemaking and Cardiac Conduction System Lineages (Robert G. Gourdie, Steven W. Kubalak, Terrence X. O'Brien, Kenneth R. Chien, Takashi Mikawa) Chapter 12: Cardiac Laterality and Congenital Heart Disease (Pilar Ruiz-Lozano, Angel Raya, Kenneth R. Chien, Juan Carlos Izpisua-Belmonte) Chapter 13: Pharyngeal Apparatus and Cardiac Neural Crest Defects (Antonio Baldini) Chapter 14: Monogenic Causes of Congenital Heart Disease (Joachim P. Schmitt, Christine E. Seidman) III. Cardiac Muscle Diseases Chapter 15: Molecular Pathways for Cardiac Hypertrophy and Heart Failure Progression (Masahiko Hoshijima, Susumu Minamisawa, Hideo Yasukawa, Kenneth R. Chien) Chapter 16: Molecular Genetics of Inherited Cardiomyopathies (Christopher Semsarian, J.F. Seidman, and Christine E. Seidman) Chapter 17: Molecular Pathways for Dilated Cardiomyopathy (K. Campbell)Chapter 18: Excitability and Conduction (Michael J. Ackerman, David E. Clapham) Chapter 19: Cardiac Arrhythmias: Inherited Molecular Mechanisms (Steve A. N. Goldstein, Mark T. Keating, Michael C. Sanguinetti) IV. Atherogenesis Chapter 20: Inflammation and Immunity in Atherogenesis (Peter Libby, Goran K. Hansson and Jordan S. Pober) Chapter 21: Molecular Biology of Lipoproteins and Dyslipidemias (Sotirios Tsimikas, Vincent Mooser) Chapter 22: Lipoprotein Oxidation, Macrophages, Immunity and Atherogenesis (Sotirios Tsimikas, Christopher K. Glass, Daniel Steinberg and Joseph L. Witztum) Chapter 23: Cellular Cholesterol Metabolism in Health and Disease (Ira Tabas) V. Ischemic Diseases and Angiogenesis Chapter 24: Angiogenesis in Cardiovascular Disease (Karen S. Moulton, Judah Folkman) Chapter 25: Coronary Restenosis (Hiroshi Ashikaga, Ori Ben-Yehuda, Kenneth R. Chien) Chapter 26: Molecular Basis for the Potential Use of NMDA Receptor Open-Channel Blockers in the Treatment of Cerebral Ischemia and Other Brain Insults (Stuart A. Lipton, Stephen F. Heinemann) VI. Thrombosis Chapter 27: Platelets and Anti-Platelet Therapy in Cardiovascular Disease: Molecular Mechanisms (Ori Ben-Yehuda) Chapter 28: Blood Coagulation and Atherothrombosis (Hiroshi Ashikaga, Kenneth R. Chien) Chapter 29: Thrombosis and Thrombolytic Therapy (H.R. Lijnen, H. Pannekoek, J. Vermylen) VII. Hypertension Chapter 30: Molecular Targets of Antihypertensive Drug Therapy (Edwin W. Williems, Ahsan Husain, Robert M. Graham) Chapter 31: Mechanisms and Molecular Pathways in Hypertension (Roger Brown, John Mullins, David J. Webb) VIII. Environmental and Genetic Modifiers of Cardiovascular Disease Chapter 32: Molecular Biology of Transplantation and Xenotransplantation (Patrick Hildbrand, Daniel R. Salomon) Chapter 33: Viral Infections of the Heart (Kirk U. Knowlton, Herve Duplain) IX. Glossary: Resources, Websites