This is the only comprehensive and up-to-date book on neurological PET. Its goal is to facilitate cooperation between PET experts, neuroscientists and clinicians. We review PET in neuroscience with particular emphasis on findings that indicate its potential for improving diagnosis and treatment in neurology and psychiatry. We want to improve the transfer of the huge scientific developments in brain PET into clinical care to produce tangible human benefit. We therefore focus on practical and potentially clinically relevant issues and identify solid ground as well as open questions. In addition, the book includes major chapters on the methodological background, including tracer physiology and kinetic modeling, and a comprehensive literature review. The book contains a CD-ROM with video clips and interactive navigation in 3D data sets that illustrate the information contained in PET images in major neurological diseases and its potential to improve diagnosis and neurosurgical planning in brain tumors.9
Indice testuale
Clinical Studies: Dementia and memory disorders. Movement disorders. Brain tumors. Cerebrovascular disease. Epilepsy. Other neurological disorders. Psychiatric disorders.- Imaging brain function: Blood-brain barrier transfer. Cerebral blood flow (CBF). Oxygen consumption. Glucose consumption. Influence of brain function on CBF and metabolism. Tissue oxygen pressure and pH. Amino acid transport and protein synthesis. Nucleosides and DNA synthesis. Molecular imaging. Dopamine system. Cholinergic system. Serotonin system. GABA. Glutamate and NMDA receptors. Adenosine receptors. Histamine receptors. Cannabinoid receptors. Opioid receptors and sigma receptor. Steroid receptors. Secondary neurotransmitters.- Data acquisition, reconstruction, modeling, statistics: Positron emitters and tracers. Scanners and detector systems. Data acquisition. Image reconstruction. Motion detection and correction. Data visualization. Anatomical standardization. Physiological modeling. Quantitative data analysis.
