Established worldwide as the one definitive, encyclopedic reference on headache, The Headaches is now in its thoroughly revised, updated Third Edition. The foremost international authorities examine the mechanisms of over 100 types of headache and provide evidence-based treatment recommendations, including extensive tables of controlled clinical trials. This edition presents the revised International Headache Society classification of headaches and explains how to use this new classification for accurate diagnosis. Many headache entities are discussed for the first time, such as chronic migraines; primary headache attributed to sexual activity; primary stabbing, cough, exertional, and thunderclap headaches; hypnic headaches; and new daily persistent headaches. A new section focuses on childhood headaches. Chapters that focus on headaches in elderly patients and patients with psychiatric or medical diseases are also included.
I. General Aspects of the Headaches History of the Headache Classification of the Headache Epidemiology of the Headache Impact of the Headache on the Individual and Family Societal Burden of the Headache History and Examination of the Headache Patient Principles of Clinical Pharmacology, Randomized Controlled Clinical Trials and Evidence-Based Medicine in the Headache Ethical Issues in Headache Research and Management II. Basic Science Aspects of the Headahces Anatomy of Muscles, Tendons, Joints, Blood Vessels, and Meninges Anatomy and Physiology of Head Pain Inhibition and Facilitation of Nociception Peripheral and Central Sensitization Related to Headaches Imaging Pain Serotonin and Other Biogenic Amines Nitric Oxide Calcitonin Gene Related Peptide and Other Peptides Sex Hormones Prostanoids and Other Inflammatory Mediators Other Molecules Affecting Pain Modulation Ion Channels Relevant to Pain Intracellular Mechanisms of Relevance to Pain Transmission Animal Models of the Headache Human Models of the Headaches III. The Migraines The Migraines: Introduction Epidemiology of the Migraine Migraine Comorbidity Genetics of the Migraine Cortical Spreading Depression 5-Hydroxytryptamine Involvement in Migraines Nitric Oxide Involvement in Migraines CGRP Involvement in Migraines Channelopathies and Their Possible Relation to Migraines Neurogenic Inflammatory Mechanisms Blood and Spinal Fluid in Migraines Influence of Female Hormones on Migraines Platelets and Immunology of Migraines Hemodynamics and Neuroimaging of Migraines Brain Metabolism in Migraines Neurophysiology of Migraines Autonomic Dysfunction in Migraines Psychological Mechanisms of Migraines Synthesis of Migraine Mechanisms Symptomatology of Migraines without Aura Migraines with Aura and Its Subforms Diagnosis and Differential Diagnosis of Migraines Prognosis of Migraines General and Pharmacological Approach to Migraine Management Psychological and Behavioral Treatments of Migraines Nonsteroidal Antiinflammatory Drugs in the Acute Treatment of Migraines Ergot Alkaloids in the Acute Treatment of Migraines Triptans, 5-HT 1B/1D Receptor Agonists in the Acute Treatment of Migraines Antiemetic, Prokinetic, Neuroleptic, and Miscellaneous Drugs in the Acute Treatment of Migraines Prioritizing Acute Pharmacotherapy of Migraines B-Adrenoceptor Blocking Drugs in Migraine Prophylaxis Antiserotonin Drugs in Migraine Prophylaxis Calcium Antagonists in Migraine Prophylaxis Antiepileptic Drugs in Migraine Prophylaxis Nonsteroidal Antiinflammatory and Miscellaneous Drugs (magnesium, botox, feverfew, riboflavinin) in Migraine Prophylaxis Prioritizing Prophylactic Treatment of Migraines Potential New Drugs for Acute and Prophylactic Treatment of Migraines Sporadic and Familial Hemiplegic Migraines Basilar Migraines and Retinal Migraines Status Migrainosus and Migraine Aura Status Migrainous Infarction, Persistent Aura Symptoms Without Stroke and Migraine Triggered Epilepsy Chronic Migraines IV. Tension-Type Headaches, Cluster Headahces, and Other Primary Headaches Tension-Type Headache: Introduction Epidemiology of Tension-Type Headaches Genetics of Tension-Type Headaches Human Studies of Experimental Pain from Muscle Sensitization of Myofascial Pain Pathways in Tension-Type Headaches Neurophysiology of Tension-Type Headaches Hemodynamics and Muscle Metabolism of Tension-Type Headaches Oromandibular Dysfunction and Tension-Type Headaches Psychological Mechanisms of Tension-Type Headaches