Contributors; 1. Progress in neurotherapeutics and neuropsychopharmacology Jeffrey L. Cummings; 2. Trifusal versus aspirin for the prevention of stroke Antonio Culebras, Javier Borja and Julian Garcia-Rafanell; 3. The Argatroban and tPA stroke study Andrew D. Barreto and James C. Grotta; 4. Use of Selegiline as monotherapy and in combination with Levodopa in the management of Parkinson's disease: perspectives from the MONOCOMB study Sven E. Palhagen and Esa Heinonen; 5. Ropinirole 24-h prolonged release in advanced Parkinson's disease: review of a randomised, double-blind, placebo-controlled study (EASE PD - adjunct study) Kelly E. Lyons and Rajesh Pahwa; 6. Insulin resistance and Alzheimer's disease: pathophysiology and treatment G. Stennis Watson and Suzanne Craft; 7. Targeting Amyloid with Tramiprosate in patients with mild-to-moderate Alzheimer's disease P. S. Aisen, R. Briand, D. Saumier, J. Laurin, A. Duong and D. Garceau; 8. Intranasal Zolmitriptan is effective and well-tolerated in acute cluster headache: a randomized placebo-controlled double-blind crossover study E. Cittadini and P. J. Goadsby; 9. Optimal dosing of immunomodulating drugs: a dose-comparison study of GA in RRMS Daniel Wynn, Catherine Meyer, Neil Allen and Dennis O'Brien; 10. Tetrathiomolybdate versus Trientine in the initial treatment of neurologic Wilson's disease George J. Brewer, Fred Askari, Matthew T. Lorincz, Martha Carlson, Michael Schilsky, Karen J. Kluin, Peter Hedera, Paolo Moretti, John K. Fink, Roberta Tankanow, Robert B. Dick and Julia Sitterly; 11. Randomized clinical trials of Pregabalin for neuropathic pain: methods, results, and implications Robert H. Dworkin, Rajbala Thakur, Teresa Griesing, Uma Sharma and James P. Young; 12. Effect of Methylphenidate in patients with acute traumatic brain injury: a randomized clinical trial Hossein A. Khalili and Kamyar Keramatian; 13. Improvement in speeded cognitive processing after anti-epileptic drug withdrawal - a controlled study in mono-therapy patients Erik Hessen, Morten I. Lossius, Ivar Reinvang and Leif Gjerstad; 14. A randomized-controlled trial of bilateral rTMS for treatment-resistant depression Paul B. Fitzgerald; 15. Serotonin related genes affect antidepressant treatment in obsessive-compulsive disorder F. Van Nieuwerburgh, D. Deforce and D. A. J. P. Denys; 16. Night eating syndrome and results from the first placebo-controlled trial of treatment, with the SSRI medication, Sertraline: implications for clinical practice John P. O'Reardon Karen E. Groff, Albert J. Stunkard and Kelly C. Allison; 17. Modafinil: a candidate for pharmacotherapy of negative symptoms in schizophrenia John H. Peloian and Joseph M. Pierre; 18. New approaches to treatment of schizophrenia by enhancing N-methyl-D-aspartate neurotransmission Guochuan Emil Tsai; Subject index; Author index.