Neonatal and Pediatric Pharmacology offers guidelines for safe, effective, and rational drug therapy in newborns, children and adolescents. The book provides relevant and useful data on the molecular, physiologic, biochemical, and pharmacologic mechanisms of drug action and therapy in this population. The authors identify areas of innovative basic and translational research necessary for the continuing evaluation and development of drugs for the fetus, newborns, children and adolescents. Neonatal and Pediatric Pharmacology is is a valuable reference for all health care professionals who treat the fetus, newborns, children, and adolescents, including neonatologists, nurses, pediatricians, general practitioners, students, obstetricians, perinatologists, surgeons and allied health professionals. It will be useful anytime during the day and especially in the middle of the night when knowledge of appropriate indications, safe and effective use, dosage, and therapeutic regimen for a certain drug or molecular entity is immediately needed.
The book is also directed to those involved in basic, clinical, and other academic pharmacological research, the pharmaceutical industry, and regulatory agencies dealing with drug and therapeutic developments for this population. Those teaching pharmacology and therapeutics will find this compilation of information extremely useful in preparing teaching materials.
Indice testuale
I: GENERAL PRINCIPLES 1: Introduction and Historical Perspectives 2: Clinical Pharmacokinetics in Infants and Children 3: Drug Action and Therapy in the Infant and Child 4: Drug Metabolism and Disposition in Infants and Children 5: Pharmacogenetics, Pharmacogenomics, and Pharmacoproteomics 6: Compliance with Pediatric Medication Regimens 7: Clinical Trials Involving Children: History, Rationale, Regulatory Framework, and Technical Considerations 8: Ethics of Drug Research in Pediatric Populations 9: Therapeutic Drug Monitoring 10: Drug Formulations II: DRUGS AND THE NEWBORN 11: Developmental Toxicology 12: Biotransformation of Medications by Human Placenta 13: Maternal Drug Intake and the Newborn 14: Principles of Neonatal Pharmacology 15: Perinatal Origins of Adult Defects in Drug Metabolism 16: Renal Function and Excretion of Drugs in the Newborn 17: The Excretion of Drugs and Chemicals in Human Milk 18: Drugs for Hyperbilirubinemia 19: Drugs and Lung Development 20: Pharmacologic Treatment of Neonatal Apnea 21: Drugs and Perinatal Brain Injury 22: Antiretroviral Pharmacology in Pregnant Women and Newborns III: DRUGS IN SPECIAL POPULATIONS AND SETTINGS 23: Therapeutic Applications in Pediatric Intensive Care 24: Drug Therapy in the Pediatric Emergency Department 25: Drug Therapy in the Adolescent 26: Topical Medications 27: Ophthalmologic Drugs in Infants and Children IV: SPECIFIC DRUGS 28: Sulfonamides 29: Penicillins, Cephalosporins, and Other Beta-Lactams 30: Aminoglycosides and Glycopeptides 31: Fluoroquinolones 32: Macrolides, Chloramphenicol, and Tetracyclines 33: Anthelminthic Drugs in Children 34: Antituberculosis Drugs 35: Antifungal Agents 36: Antiviral Drugs: Treatment of the Fetus and Newborn 37: Anticonvulsants 38: Psychopharmacology in Children and Adolescents 39: Antihistamine Drugs 40: Antiasthmatics 41: Antipyretics 42: Cardiovascular Drugs 43: Diuretics 44: Clinical Pharmacology of Antineoplastic Drugs 45: Immunosuppressive and Immunomodulatory Drugs 46: Analgesic Agents 47: Local Anesthetics for Infants and Children 48: Nonsteroidal Anti-inflammatory Drugs 49: Antihypertensive Agents 50: Gastrointestinal Drugs 51: Glucocorticoids 52: Insulin and Diabetes Mellitus 53: Thyroid Hormones 54: Growth Hormone 55: Hematologic Agents 56: Nutrient Supplements 57: Childhood Vaccines V: ADVERSE DRUG EFFECTS AND INTERACTIONS 58: Epidemiology of Adverse Drug Effects 59: Mechanisms of Adverse Drug Reactions 60: Medication Errors 61: Pediatric Poisonings and Antidotes 62: Use of Herbal Products in Children: Risks and Unproven Benefits 63: Neonatal Abstinence Syndromes 64: Drug Interactions in Newborns and Children VI: APPENDIX 65: Drug Formulary for the Newborn 66: Pediatric Drug Formulary
