This book addresses the biological, moral and legal issues which arising prenatal testing of late onset neurogenetic disease. The contributors focus specifically on Huntington's Disease, which is used as a model for other late onset neurogenetic diseases. The ethical and legal aspects of prenatal testing and preimplantation genetic diagnosis are discussed with reference to case histories. This volume will provide valuable insights for all those involved in dealing with these challenging issues.
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1. Introduction: Complexity of Predictive and Prenatal Testing for Neurogenetic Late-Onset Diseases. 2. Case Histories of Prenatal Testing for Huntington's Disease. 3. An Overview of Prenatal Testing for Huntington's Disease in Six European Countries. 4. Reproductive History after Predictive Testing for Huntington's Disease: A European Collaborative Study. 5. Predictive and Prenatal Testing for Huntington's Disease in Greece, Germany, Austria, Switzerland and Denmark. 6. Legal Aspects of Prenatal Testing Late-Onset Neurological Diseases. 7. Preimplantation Genetic Diagnosis for Huntington's Disease. 8. Case Histories About Preimplantation Genetic Diagnosis. 9. Ethical Aspects of Prenatal Testing and Preimplantation Genetic Diagnosis for a Late-Onset Neurogenetic Disease: The Case of Huntington's Families. 11. Predictive and Prenatal Testing for Autosomal Dominant Cerebellar Ataxias. 12. Counselling Aspects of Prenatal Testing for Late-Onset Neurogenetic Diseases. 13. Predictive and Prenatal Testing for Late-Onset Neurogenetic Diseases in North America. 14. Conclusions: Prenatal Testing for Late-Onset Genetic Disorders: Evidence and Insights from Huntington's Disease.
