This book is a comprehensive review of vasculitis, a fascinating array of life-threatening and minor conditions caused by inflammatory syndromes and diseases that affect the blood vessels. It brings together in a unique way, concepts from both the biology and clinical aspects of vasculitis. Research in clinical immunology now invigorates the entire area of vasculitis, and shapes a rational approach to pathogenesis, diagnosis and treatment which is the substance of this text. Over 40 chapters cover known vasculitic conditions, and are illustrated with numerous photographs, diagrams and tables. Some chapters, such as that of aortitis, are brief, and others, such as those devoted to Behcet's disease, are much longer, in keeping with their prevalence. The authors have been chosen based on their unique experiences with vasculitic conditions. Most of these conditions are rare in most areas of the globe, and it is the exceptional clinician who has much experience with more than a few of these; thus, drawing upon authors from all over the world has enabled the editors to provide informed discussions of all of them.
The book is illustrated with numerous colour illustrations of clinical manifestations and also contains superb illustrations of invasive and non-invasive imaging. This book is directed primarily at general internists, rheumatologist and clinical immunologists, but will also be of interest to dermatologists, gastroenterologists, pulmonologists, nephrologists, neurologists, pathologists and vascular surgeons.
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INTRODUCTION; Classification of Vasculitic Syndromes; BASIC SCIENCE; Hypersensitivity; Biology of Endothelial Cells; Pathogenesis of Vasculitis; CLINICAL MANIFESTATIONS COMMON TO VASCULITIS; Cutaneous Manifestations; Oral Ulcers; Ophthalmologic Manifestations; Pulmonary Manifestations; Vasculitic Neuropathy; Renal Manifestations; Digital Ischemia and Raynaud's Phenomenon; IMAGING STUDIES IN DIAGNOSIS OF VASCULITIS, AND PERCUTANEOUS INTERVENTIONS; Angiography and Percutaneous Interventions; Cross-Sectional Imaging in Vasculitis; VASCULITIC DISEASES AND SYNDROMES, AND RELATED DISORDERS; Epidemiology of Vasculitis; An Approach to the Adult with Suspected Vasculitis; An Approach to the Child with Suspected Vasculitis; Assessment of Disease Activity and Damage; Giant Cell Arteritis and Polymyalgia Rheumatica; Takayasu's Arteritis; Tropical Aortitis (Tropical Vasculitis) and Lepromatous Vasculitis; Polyarteritis Nodosa and Microscopic Polyangiitis; Cutaneous Polyarteritis; Kawasaki's Disease; Wegener's Granulomatosis: Pathogenesis; Wegener's Granulomatosis: Clinical Aspects; Wegener's Granulomatosis: Treatment; Churg-Strauss Syndrome; Vasculitis in Primary Connective Tissue Diseases; Behcet's Syndrome: Pathogenesis, Clinical Manifestations, and Treatment; Behcet's Syndrome: Immunogenetics; Juvenile Behcet's Syndrome; Vasculitis of the Central Nervous System; Thromboangiitis Obliterans (Buerger's Disease); Cutaneous Leukocytoclastic Vasculitis; Henoch-Schonlein Purpura; Cryoglobulinemic Vasculitis; Miscellaneous Forms of Vasculitis; Experimental Therapies for Vasculitis; Antiphospholipid Syndrome; Imitators of Vasculitis
