Written and edited by the world's foremost authorities, the Second Edition of this landmark work is a current, comprehensive reference on cerebral blood flow and metabolism. The book covers the entire field in a systematic and coherent way and synthesizes the diverse body of basic science and clinical literature. The reader will gain a complete understanding of the anatomical, physiological, and pharmacological bases of the cerebral circulation, its regulation in health and disease, and the pathophysiological disturbances occurring in cerebrovascular disorders. Coverage includes stimulating discussions of future directions for research and therapeutic intervention
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Prologue David Ingvar Part I. The Anatomical Bases 1. General and Comparative Anatomy of the Cerebral Circulation Lars Edvinsson and Eric T. MacKenzie. 2. The Blood Vessel Wall: Endothelial and Smooth Muscle Cells Lars Edvinsson 3. Perivascular Nerve Fibers in Brain Vessels Lars Edvinsson and Edith Hamel. Part II. The Physiological Basis 4. Ion channels Mark T. Nelson. 5. Vascular Smooth Muscle Reactivity in Vitro and in Situ William J. Pearce 6. Endothelial Regulation Diana N. Krause 7. The Blood Brain Barrier: Permeability, Substrate Transport and Drug and Gene Targeting William M. Pardridge 8. Energy Generation in the Central Nervous System Gerald A. Dienel 9. Neurotransmitters: Metabolic and Vascular Effects in Vivo Pierre Magistretti 10. Neurovascular control of the cerebral circulation. Peter J Goadsby Part III. The Pharmacological Bases 11. Catecholamines Lars Edvinsson and Diana N.Krause 12. Neuropeptide Y Lars Edvinsson and Diana N.Krause 13. Acetylcholine Pierre Lacombe and Edith Hamel 14. Calcitonin Gene Related Peptide: Vascular Localization and Role in Cerebrovascular Disorders Stefanie A. Kane and Kenneth S. Koblan 15. Neuropeptides Lars Edvinsson and Diana N.Krause 16. 5-Hydroxytryptamine and it's Receptors Richard Hargreaves 17. Nitric Oxide Costantino Iadecola and Kiyoshi Niwa 18. Purines, Purine Nucleotides and Pyrimidine Nucleotides Robert M. Bryan Jr. 19. Prostaglandins and Other Eicosanoids David Busija 20. Endothelin Jacob Hansen-Schwartz and Lars Edvinsson 21. Histamine Lars Edvinsson and Anders Ottosson 22. Cytokines and the Cerebral Circulation William J. Pearce Part IV. Fundamental Responses of the Cerebral Circulation 23. Measuring Cerebral Blood Flow and Metabolism Ulrich Dirnagl, Lars Edvinsson, and Arno Villringer 24. Changes in Arterial Gas Tensions Patricia D. Hurn and Richard Traystman 25. Autoregulation: Arterial and Intracranial Pressure Jean-Marc Chillon and Gary L. Baumbach 26. Functional Brain Imaging Marcus E. Raichle and Lars Edvinsson Part V. Disordered Control - Pathophysiological Aspects 27. Molecular Mechanisms of Ischemic Brain Damage Tadeusz Wieloch 28. Neuroprotection in Stroke Therapy Kenneth R. Lees and Hans-Christoph Diener 29. Primary Neurovascular headache:Migraine and Cluster headache Peter Goadsby, Arne May 30. Subarachnoid Haemorrhage and cerebral circulation. Jacob Hansen-Schwartz 31. Aging and Dementia. INDEX
