Leading researchers synthesize scattered experimental data to help develop an intimate understanding of how cytokines and chemokines are involved in the pathogenesis of autoimmune diseases. The many chapters offer critical reviews the basic mechanisms controlling cytokine induction and regulation, as well as the resulting production of proinflammatory and anti-inflammatory cytokines, the former of which induces organ-specific autoimmune diseases. From the vantage of these insights, they address the role of cytokines in a wide variety of autoimmune diseases, uvetis, encephalomyelitis, multiple sclerosis, human type 1 diabetes, rheumatoid arthritis, SLE, and myasthenia gravis. Authoritative and state-of-the-art, Cytokines and Autoimmune Disease highlights the enormous therapeutic potential of cytokine modulation in the treatment of autoimmune disease.
Indice testuale
Part I. Cytokines: Induction and Regulation Transcriptional Regulation of Cytokine Gene Expression in The Subsets Jyothi Rengarajan and Laurie H. Glimcher Chromatin Remodeling and Transcriptional Regulation of Cytokine Gene Expression in T Cells M. Frances Shannon and Adele F. Holloway Variant Ligands, Altered T Cell Receptor Signaling, Hierarchial Response Thresholds, and CD4+ Effector Responses Yasushi Itoh and Ronald N. Germain The Role of Costimulation in T Cell Differentiation Janet E. Buhlmann and Arlene H. Sharpe CD1d-Restricted NK T Cells and Autoimmunity Mark Exley and S. Brian Wilson Role of T Cell Death and Cytokines in Autoimmunity Luk Van Parijs and Abul K. Abbas Role of Chemokines and Their Receptors in the Induction and Regulation of Autoimmune Disease Richard M. Ransohoff and William J. Karpus Part II. Cytokines: Role in Specific Autoimmune Diseases Cytokines and Resistance to Organ Specific Autoimmune Disease Benjamin M. Segal and Ethan M. Shevach The Role of Cytokines in Induction and Regulation of Autoimmune Uveitis Rachel R. Caspi Pathogenic and Regulatory Cytokines in Experimental Autoimmune Encephalomyelitis Estelle Bettelli and Lindsay B. Nicholson Role of Cytokines in Multiple Sclerosis and Mucosal Tolerance Howard L. Weiner Cytokines and Human Type 1 Diabetes Sally C. Kent, Vissia Viglietta, and David A. Hafler Cytokines in Human Rheumatoid Arthritis and Murine Models Marie Wahren-Herlenius, Helena Erlandsson Harris, Per Larsson, and Lars Klareskog Systemic Lupus Erythematosus Amy E. Wandstrat and Edward K. Wakeland Myasthenia Gravis Premkumar Christadoss and Elzbieta Goluszko Part III. Cytokines and Autoimmunity: A Synthesis Cytokines in Autoimmune Disease Vijay K. Kuchroo and Lindsay B. Nicholson
