International experts not only review the state-of-the-art in managing children and adults with acute leukemia, but also debate the pros and cons of current controversial and problematic issues. The book summarizes the best diagnostic and treatment practices for acute leukemias in children, adolescents, and adults. Among the therapies discussed are methotrexate, asparaginase, antipurines, epipodophyllotoxins, hematopoietic stem cell transplantation, hematopoietic growth factors, and immunotherapy.
Indice testuale
Part I: Diagnosis, Classification, and Prognosis Classification of Acute Leukemias: Perspective 1 Wolf-Dieter Ludwig, Torsten Haferlach, and Claudia Schoch Classification of Acute Leukemias: Perspective 2 Frederick G. Behm Part II: Chemotherapeutic Strategies A. Infant Leukemias Biology and Treatment of Infant Leukemias: Perspective 1 Rob Pieters Biology and Treatment of Acute Leukemias in Infants: Perspective 2 Gregory H. Reaman B. Childhood Acute Lymphoblastic Leukemia Treatment of Childhood Acute Lymphoblastic Leukemia Martin Schrappe and Martin Stanulla Treatment of Childhood Acute Lymphoblastic Leukemia: The Dana-Farber Cancer Institute ALL Consortium Perspective Lewis B. Silverman and Stephen E. Sallan C. Acute Lymphoblastic Leukemia in Adolescents and Young Adults Treatment of Acute Lymphoblastic Leukemia in Adolescents and Young Adults: Lessons Learned and Future Directions Sima Jeha and Hagop M. Kantarjian Treatment of Adolescents and Young Adults with Acute Lymphoblastic Leukemia: Children's Cancer Group Trials James Nachman D. Acute Lymphoblastic Leukemia in Adults Treatment of Adult Acute Lymphoblastic Leukemia: Perspective 1 Spero R. Cataland and Richard A. Larson Treatment of Adult Acute Lymphoblastic Leukemia: Perspective 2 Dieter Hoelzer and Nicola Gokbuget E. Central Nervous System Therapy for Acute Lymphoblastic Leukemia Central Nervous System-Directed Therapy for Acute Lymphoblastic Leukemia Judith M. Chessells Diagnosis, Prophylaxis, and Treatment of Central Nervous System Involvement in Acute Lymphoblastic Leukemia Anjo J. P. Veerman F. Relapsed Acute Lymphoblastic Leukemia Treatment of Relapsed Acute Lymphoblastic Leukemia: Perspective 1 Helmut Gadner, Georg Mann,and Christina Peters Treatment of Relapsed Acute Lymphoblastic Leukemia: Perspective 2 Gunter Henze and Arend von Stackelberg G. B-Cell Acute Lymphoblastic Leukemia Treatment of B-Cell Acute Lymphoblastic Leukemia: Perspective 1 Catherine Patte Treatment of B-Cell Acute Lymphoblastic Leukemia: Perspective 2 John T. Sandlund H. Acute Myeloid Leukemia in Children Treatment of Acute Myeloid Leukemia in Children Ursula Creutzig Treatment of Childhood Acute Myeloid Leukemia David M. Loeb and Robert J. Arceci I. Acute Myeloid Leukemia in Adults Therapy of Acute Myeloid Leukemia in Adults Bob Lowenberg Treatment of Adult Acute Myelogenous Leukemia Ricardo T. Spielberger and Stephen J. Forman J. Acute Promyelocytic Leukemia Acute Promyelocytic Leukemia: Perspective 1 Zhu Chen and Zhen-Yi Wang Acute Promyelocytic Leukemia: Perspective 2 Francesco Lo Coco, Giuseppe Avvisati, and Franco Mandelli K. Childhood Leukemias in Underprivileged Countries Treatment of Childhood Leukemias in Underprivileged Countries Bharat Agarwal and Rashmi Dalvi How to Confront the Problem of Treatment of Childhood Leukemias in Underprivileged Populations Giuseppe Masera and Andrea Biondi Part III: Antileukemic Drugs A. High-Dose Methotrexate in Childhood Acute Lymphoblastic Leukemia Rationale for High-Dose Methotrexate in Childhood Acute Lymphoblastic Leukemia Timothy L. Brenner and William E. Evans Role of Methotrexate in the Treatment of Acute Lymphoblastic Leukemia Bruce M. Camitta and Barton A. Kamen B. Asparaginase Asparaginase Barbara L. Asselin and Joanne Kurtzberg Asparaginase Treatment Carmelo Rizzari C. Antipurines in Childhood Acute Lymphoblastic
