The emphasis of this book is on mechanisms and pathways regulating the expression and actions of classical and novel tumor angiogenesis regulators. The contributors discuss their underlying biology as well as anti-angiogenic drugs currently in use to fight different cancers. The book provides an insight on how factors such as obesity, diabetes, and other metabolic disorders can influence the development and growth of cancer. It is of significant interest not only to oncologists but also to a wide range of medical practitioners and researchers.
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VEGF Signaling in Normal and Tumor Angiogenesis, Evangelia Pardali, Rinesh Godfrey and Johannes Waltenberger Regulation of Angiogenesis via Notch Signaling in Human Malignancy, Shanchun Guo, Mingli Liu, Lily Yang, Guangdi Wang and Ruben R. Gonzalez-Perez Endothelial and Cancer Stem Cell Regulation of Tumor Angiogenesis, Mingli Liu, Lily Yang, Shanchun Guo and Ruben R. Gonzalez-Perez Differential Activation of Macrophages in Tumors: Roles in the Regulation of Tumor Development and Angiogenesis, Shalini P. Outram and S. Joseph Leibovich Paracrine and Autocrine Control of Endothelial Cell Function by Inflammatory and Bioactive Lipid Mediators: Relevance for Tumor Angiogenesis, Charlotte E Farrar, Alexandra McSloy, Elena Garonna and Caroline PD Wheeler-Jones Tumor Angiogenesis Regulators in Breast Cancer: Does Race matter? Laronna S. Colbert and Taliaferro-Smith Regulation of Tumor Angiogenesis by Non-Classical Factors: Peptide and Protein Factors, Lipid and Steroid Factors and by Other Novel Small Molecules, Gary L. Sanford, Ravindra Kumar and Tanisha McGlothen The Role of Cyclooxygenases and Lipoxygenases in the Regulation of Tumor Angiogenesis, Graham Pidgeon Cathepsins and Other Proteases in Tumor Angiogenesis, Manu O. Platt and Jerald E. Dumas Kruppel-like factor 5 (KLF5) and Tumor Angiogenesis, Rohinton S. Tarapore and Yizeng Yang Signatures of Heightened Angiogenesis in Gynecologic Cancers: The Promise of Innovative Therapies, Whitfield Growdon, Rosemary Foster, Leslie Bradford and Bo R. Rueda Obesity, Diabetes and Metabolic Syndrome Impact on TUMOR ANGIOGENESIS, Joao Incio and Raquel Soares
