In Hormone Therapy in Breast and Prostate Cancer, many of today's leading researchers and clinicians describe the principles underlying targeted hormonal treatments, assess the actions of new and established agents, and illustrate the new applications of hormonal chemoprevention for breast cancer. Topics range from preclinical and clinical antiestrogens to the inhibition of estrogen synthesis and the effects of androgen withdrawal. A wide variety of proven and new agents are discussed-antiestrogens, including aromatase inhibitors (anastrozole, letrozole, and others), SERMs (tamoxifen, raloxifene, and others), and such antiandrogenic strategies as goserelin and bicalutamide.
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An Introduction to the Regulation of Sex Steroids for the Treatment of Cancer V. Craig Jordan and Barrington J. A. Furr Part I. Preclinical Antiestrogens Antiestrogens and the Cell Cycle Colin K. W. Watts, Owen W. J. Prall, Jason S. Carroll, Nicholas R. C. Wilcken, Eileen M. Rogan, Elizabeth A. Musgrove, and Robert L. Sutherland Drug Resistance to Antiestrogens Ruth M. O'Regan, Anait S. Levenson, Gale M. England, Kathy A. Yao, Henry D. Muenzner, Hiroyuki Takei, and V. Craig Jordan Mechanisms of Liver Carcinogenesis by Antiestrogens David H. Phillips The Effects of Triphenylethylene Antiestrogens on Parameters of Multistage Hepatocarcinogenesis in the Rat Yvonne P. Dragan and Henry C. Pitot Preclinical Studies of Raloxifene and Related Compounds Robin Fuchs-Young. Pure Antiestrogens, Alan E. Wakeling Part II. Antiestrogens: Clinical Tamoxifen for the Treatment of Breast Cancer V. Craig Jordan Clinical Utility of New Antiestrogens Ruth M. O'Regan and William J. Gradishar Breast Cancer Prevention with Antiestrogens Monica Morrow and V. Craig Jordan Part III. Inhibition of Estrogen Synthesis Aromatase Inhibitors Paul E. Goss and Caroline C. Reid Clinical Utility of Aromatase Inhibitors K. Shenton, Mitchell Dowsett, and Michael Dukes LH-RH Agonists for the Treatment of Breast Cancer: Development and Current Status Roger W. Blamey Part IV. Androgen and Androgen Withdrawal Molecular Action of Androgens Shutsung Liao, Junichi Fukuchi, and Yung-Hsi Kao Steroidal Antiandrogens Fritz H. Schroder and Albert Radlmaier Nonsteroidal Antiandrogens Geert J. C. M. Kolvenbag and Barrington J. A. Furr LH-RH Agonist Role in Prostate Cancer Management Amir V. Kaisary Part V. Perspective on Progress Recent Progress in Breast Cancer Research V. Craig Jordan and Barrington J. A. Furr
