The human oocyte or egg is the rarest and most rapidly ageing cell in the body, and yet one that is essential for fertility. This 2003 book is about the development, biology and pathology of the oocyte, and technologies to manipulate, enhance and control fertility. These technologies are paving the way for overcoming infertility, avoiding inherited diseases and creating genetically engineered animals from embryo stem cells and cloning. This progress would have been impossible without the myriad of scientific and technical developments covered in this book, including the ability to manipulate and fertilize oocytes in vitro. World-leading experts provide contributions on basic and applied science of the egg, its clinical manipulation, and its pivotal role in reproductive medicine and biology.
Indice testuale
Preface; Part I. Historical Perspective: 1. The magic and mystery of the oocyte: ex ovo omnia Roger Short; Part II. Life Cycle: 2. Ontogeny of the mammalian ovary Anne Grete Byskov and Majken Neilsen; 3. The early stages of follicle growth Alain Gougeon; 4. Modelling the dynamics of ovarian follicle utilisation throughout life M. J. Faddy and Roger Gosden; 5. Comparative aspects of oogenesis Mary Bownes and Stephen Pathirana; Part III. Developmental Biology: 6. Oocyte-specific gene expression: roles in folliculogenesis, fertilization and early development Jurrien Dean; 7. Morphology and pathology of the human oocyte A. Henry Sathananthan; 8. Storage and functional recovery of molecules in oocytes V. Duranthon and J. P. Renard; 9. Endocrine regulation of meiosis - local and systemic hormonal influences J. K. Findlay; 10. Checkpoint controls in mammalian oocytes Yanfeng Dai, Robert Moor and Josef Fulka Jr; 11. Fertilization: fate of sperm components after ICSI Laura Hewitson, Joao Ramalho-Santos, Calvin Simerly and Gerald Schatten; 12. Activation of the mammalian egg Philippe Collas and Rafael Fissore; 13. Clinical application of symmetry, asymmetry and polarity in early human development Jonathan Van Blerkom; Part IV. Pathology: 14. The legacy of mitochondrial DNA Eric A. Shoubridge; 15. Aneuploidy in ageing oocytes and after toxic insult Ursula Eichenlaub-Ritter; 16. Genetic basis of primary ovarian failure Gerard S. Conway and Sophie Christin-Maitre; Part V. Technology and Clinical Medicine: 17. Growth and development of the mammalian oocyte-granulosa cell complex in culture John J. Eppig; 18. Human oocyte maturation in vitro Alan Trouson; 19. Follicular factors affecting oocyte maturation and development competence Marc-Andre Sirard; 20. Low temperature storage of follicular and ovulated oocytes Roger G. Gosden; 21. Fecundity of transplanted ovaries J. M. Shaw; Index.
