Malattie neuromuscolari

La necessità di rivedere ed aggiornare questo testo dedicato ai disordini dello sviluppo motorio nasce dalla rapidità con la quale, negli anni recenti, le Neuroscienze hanno arricchito il patrimonio di conoscenze in questo ambito. Ciò ha contribuito ad una miglior comprensione dei processi che sottendono lo sviluppo delle funzioni adattive, al chiarimento di molti meccanismi patogenetici di disordini dello sviluppo, alla definizione di strumenti diagnostici più precisi ed utili per la valutazione di outcome ed infine alla diffusione, fra i clinici, dell'esigenza di basare l'intervento riabilitativo sull'evidenza scientifica. Il contributo di conoscenze più significativo degli ultimi anni proviene dalle nuove tecnologie di neuroimaging e di neurofisiologia. Le tecniche avanzate di Risonanza Magnetica, come la tecnica di Diffusione per lo studio della sostanza bianca, permette di evidenziare le caratteristiche delle lesioni cerebrali nelle fasi precoci e le modalità di riorganizzazione neuronale postlesionale, favorendo una miglior comprensione della plasticità del sistema nervoso.

Given the evolution of cerebrospinal testing (CSF) testing methods, the near future is certain to see an explosion of new CSF analysis methodologies. Broad-based and extensively illustrated, "Cerebrospinal Fluid in Clinical Practice" provides in-depth coverage of CSF examination and analysis, CSF physiology and pathophysiology, approach to diagnosis, and future directions in CSF analysis. It examines the alterations of the composition of CSF in relation to diseases and disorders of the nervous system, emphasizing the findings that are useful in clinical practice. This expansive reference is perfect regardless of your level of experience in central nervous system diseases.

Provides a comprehensive update on therapies for Parkinson's disease and other movement disorders Describes the basic mechanisms of neurodegeneration, pharmacologic interventions for motor and non-motor symptoms, and surgical management Features summary tables and algorithms that serve as a quick reference guide for practical treatment decisions The expert guidance of recognised authorities will enable readers of this book to plan their patients' care with greater confidence

Most strokes are attributed to atherosclerosis of neck and intracranial arteries, brain embolism from the heart, and penetrating artery disease; these are discussed in detail in many other books. This compendium fills an important niche by providing authoritative discussions on the other, less common causes of stroke, including various forms of angiitis, coagulation disorders, infective, paraneoplastic and metabolic disorders that may be associated with stroke, and a number of rare syndromes such as Eales disease and Fabry's disease. This new edition contains detailed, up-to-date information about the nature, diagnosis, and treatment of those relatively uncommon types of cerebrovascular disease that cause strokes. It is therefore a unique scientific and clinical resource that provides a useful reference to help physicians diagnose and treat stroke patients who do not fit well into the usual clinical categories. New chapters include stroke in patients with Lyme disease, scleroderma, Cogan's syndrome, Chagas' disease, and HIV.

This volume provides concise and comprehensive information on neuromuscular disorders, including rapid advancements in the understanding of the neurobiology of neuromuscular transmission. In addition, clinicians will find timely discussions on the various forms of these disorders that have been discovered due to increased study within the field. New observations into the immunopathogenesis of myasthenia gravis, and the molecular mechanisms underlying the links between activity and patterns of gene expression, particularly in muscle, are also explored, along with novel information on the understanding of the pathophysiology of the heterogeneous group of peripheral nerve hyperexcitability syndromes. Each of these valuable insights, and their accompanying explanations, provides a framework on which new therapeutic strategies can be built to aid in the enhancement and restoration of normal function in neuromuscular junction disorders. It offers new insights into the study of neuromuscular junction disorders, including rapid advancements in the field. It provides comprehensive information on the neuromuscular junction, and a detailed examination of myasthenia gravis and other disorders. A new framework upon which to build therapeutic strategies that will enhance the restoration of normal function in neuromuscular disorders.

Everything you need to know about neuromuscular disease--in one concise, full-color volume "...this book will become an indispensable resource for clinicians involved in the diagnosis and management of patients with neuromuscular diseases, as well as for scientists working on the nature and pathogenesis of these disorders. It is a much-needed and welcome addition to the neurological literature and will rapidly gain acceptance as a standard work of reference."--Michael J. Aminoff, MD, DSc, FRCP, (from the foreword) Neuromuscular Disorders is comprehensive in scope, yet concise enough to serve as a valuable point-of-care guide for your day-to-day clinical practice. Grounded by numerous reference sources and enhanced by the experience of two seasoned clinicians, this text provides a pragmatic approach to the evaluation and management of neuromuscular disease. Here, in a single source, you'll get an insightful look at both nerve and muscle conditions, ranging from motor neuron diseases to neuropathies, neuromuscular junction disorders, and myopathies. The book opens with the clinical and laboratory approach to patients with neuromuscular disease, covering electrodiagnostic testing, nerve conduction studies, and muscle and nerve histopathology. With an emphasis on effective diagnosis and treatment, the substance of the text examines the full spectrum of specific neuromuscular diseases, giving you the "big picture" of the discipline in a way that no other text can match. FEATURES: Convenient coverage of both nerve, muscle and neuromuscular transmission disorders--both primary and secondary neuromuscular diseases Specific disease sections encompass the range of conditions likely to be encountered in clinical practice, including amyotrophic lateral sclerosis, myasthenia gravis, radiculopathies and plexopathies, mononeuropathies, various polyneuropathies, toxic myopathies, and dozens more The very latest diagnosis and treatment recommendations and protocols based on the most recent clinical literature and research Well-illustrated with EMGs, histopathology, and clinical photos

Synthesizing the expert clinical advice of specialists who treat disorders of the nervous system, this book is an accessible, single-volume resource for primary care physicians requiring practical information on a range of neurological disorders. A Guide to the Primary Care of Neurological Disorders provides readers with a firm foundation in neuroscience concepts that will enable them to make timely diagnostic, treatment, and referral decisions about common symptoms, including chronic pain, headache, seizures, numbness, and dizziness. Additional chapters cover specific categories of neurological disease, providing the reader with concise descriptions of the clinical manifestations, examination techniques, and treatment options for each. Features: --An outline at the start of each chapter aids rapid location of topics of interest --Thorough coverage of history-taking and the physical examination --"Pearls" and "Pitfalls" at the end of each chapter review fundamental concepts and provide helpful guideposts for managing each clinical situation Packed with essential information on clinical neurosciences, this comprehensive book is ideal for primary care physicians, nurse practitioners, physicians' assistants, residents in primary care specialties, and medical students.

Clinics in Developmental Medicine Nos. 173-4 Comprehensive review of current methods of management and evaluation of the motor disorders of cerebral palsy. * Features the whole range of orthopaedic surgical procedures with commentary on each * Reviews the current epidemiology in the subject, offering perspective on prevention * Provides tables of gross motor performance to assess the measure of effectiveness of physical therapy * Describes methods of management, including: assistive technology, selective posterior rootlet rhizotomy, Botulinum toxin intramuscular injections and intrathecal Baclofen.

Building on his earlier single-authored text, James Gage has recruited a team of experts from the range of disciplines involved in managing gait problems in cerebral palsy to make this book a state-of-the art resource. They examine the way the brain controls locomotion and the types of brain pathology present in cerebral palsy. Current treatment modalities and treatments of specific gait problems are discussed in detail, including modern computerized gait analysis and methods of assessing the child and evaluating treatment outcomes. An attached CD-ROM gives pre- and post-treatment examples and illustrates visually the process of gait analysis. Clinicians, therapists and bioengineers will find this a uniquely useful resource.

This volume in the "Handbook of Clinical Neurology" (Series Editors: Michael J. Aminoff, Department of Neurology, University of California, San Francisco, USA; Francois Boller, Bethesda, USA; Dick F. Swaab, Netherlands Institute for Neuroscience, Amsterdam, the Netherlands) on motor neuron disorders and related diseases deals with the remarkable advances that have occured in recent years in the understanding of these disorders and their underlying molecular pathogenesis. An account is also provided of the general clinical features and mangement of these devasting disorders, which will be invaluable to all those who care for patients affected by them.

The revised and updated second edition of this comprehensive text continues to offer careful critical evaluation and authoritative advice on stroke, the most complicated disease affecting the nervous system of children and young adults. New chapters, the latest guidelines from the American Heart Association, tips for preventing misdiagnoses, and more provide you with the knowledge you need to make the best clinical and management decisions of both common and rare cerebrovascular disorders in the young population. Tightly focused, this fully referenced textbook fills the void in the literature by including detailed discussions on topics such as stroke in neonates, atherosclerotic cerebral infarction in young adults, strokes caused by migraines, stroke during pregnancy, and a myriad of others. Up-to-date tables containing rich troves of data along with the careful selection of multiple references further enhances your acumen.

This volume provides a comprehensive guide to myopathies, including breakthroughs that have led to a wider appreciation of the nature of these muscle diseases. Chapters on congenital muscle disorders, biological changes, and diseases associated with aging are included, along with detailed discussions of mitochondrial myopathies, disorders of carbohydrate and lipid metabolism, and the role of heredity, amongst others. Neurologists, myopathologists, and other professionals dealing with this broad group of diseases will find state-of-the-art information on the clinical investigation and management of patient care, as well as the latest information on the pathological basis and molecular pathogenesis of these diseases. It is a comprehensive guide to myopathies, including the pathological basis and molecular pathogenesis of these diseases. Informative information on complex topics, including congenital muscle disorders, the role of heredity, and age related illness, amongst others. It is a state-of-the-art guide that presents invaluable information on clinical investigation and techniques for the management of patient care.

This is a volume in the "Handbook of Clinical Neurophysiology" series on peripheral neuropathies.

This book examines the role of neurons in Multiple Sclerosis (MS) and the changes that occur in neurons as a result of MS. It places MS in a new and important perspective that not only explains the basis for symptom production, remission, and progress in MS, but also promises to open up new therapeutic possibilities. It brings together the latest information from clinical, pathological, imaging, molecular, and pharmacological realms to explore the neurobiology of Multiple Sclerosis. It is superbly illustrated and referenced.

One hundred years have passed since the first clinical descriptions of dystonia cases appeared in the literature. In the ensuing century, the study of this protean movement disorder has undergone a turbulent evolution, with dramatic shifts in the views regarding its causation and phenomenology. Considered for a period of time as a psychological or psychiatric condition, the dystonias are now recognized, in the majority of cases, as an organic neurological disorder. The clinical signs and symptoms manifested in patients with various dystonic disorders are extremely varied, so while it is one of the most common movement disorders, it is perhaps the most misunderstood and least clinically recognized. With chapters contributed by experts from both sides of the Atlantic, Clinical Diagnosis and Management of Dystonia provides a comprehensive review of the pathogenesis of dystonia, an overview of the classification of the various dystonic disorders, and a summary of the latest developments in treatment, including emerging pharmacological therapies and the use of botulinum toxin.