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Biologia molecolare

Gastrulation From Cells to Embryo


Stern, C. D.

editore: Cshl Press

pagine: 730

149,00 126,65

Antibody engineering

Methods and Protocols - Modern in molecular biology VOL. 248

Lo, C. K. B.

editore: Humana Press

pagine: 560

171,00 145,35

Adult stem cells


Turksen, K.

editore: Humana Press

pagine: 346

135,00 114,75
420,00 357,00

Blood-spinal Cord and Brain Barriers in Health and Disease

Hari Shanker Sharma

editore: Academic Press Inc

pagine: 605

Recent research into the anatomy and pathophysiology of the blood-brain and blood-spinal cord barriers suggests that a breakdown in these barriers can result in several diseases affecting the central nervous system (CNS). This book presents new findings in the area of blood-brain barrier research that suggest barriers play important roles in health and disease conditions. It also discusses the development of new drugs that can modulate the barrier function in the CNS and may provide new approaches to treating neurological diseases such as Alzheimer's disease and other motor neuron diseases, as well as spinal cord trauma. This book presents the recent progress made in the research on the blood-brain and spinal cord barrier. It contains numerous illustrations of light and electron micrographs. It also includes Foreword written by two eminent researchers in the field, Milton Brightman and Jorge Cervos-Navarro.
193,00 164,05

Prion Biology and Diseases

Stanley B. Prusiner

editore: Cold Spring Harbor Laboratory Press,U.S.

pagine: 1050

This volume is a new edition of the most authoritative book on Prion Biology, first published in 1999 and edited by the Nobel Prize-winning founder of the field. This expanded edition has been completely updated, and includes chapters on therapeutics, and diagnostic methods and approaches.
140,00 119,00

Principles of Molecular Pathology

Anthony A. Killeen

editore: Humana Press Inc.

pagine: 333

Anthony Killeen, MD, PhD, offers a comprehensive yet concise introduction to molecular pathology that encompasses both applied and theoretical knowledge. Writing in a very readable style, the author reviews the basic concepts of human molecular biology, explains the principles of the most commonly used analytical methods, and discusses the molecular principles that underlie both inherited diseases and acquired genetic abnormalities that lead to cancer. Using common viral infections as examples, the book applies these molecular methods to the detection of microbial pathogens. The growing importance of pharmacogenetics and identity testing in the clinical laboratory is also highlighted.
136,00 115,60

Stem Cells Handbook

Stewart Sell

editore: Humana Press Inc.

pagine: 522

This survey on the "state-of-the-science" of stem cell biology explains the origins of stem cells and describes how they function, how they can cause illness, and how they might be employed to cure or ameliorate disease. In particular, the authors discuss the roles of stem cells in development and organogenesis, in normal tissue turnover, in the repair response to injury, and in carcinogenesis. They also explain how to obtain stem cells from different organs, culture them in vitro, and manipulate them for therapeutic use.
175,00 148,75

Cytokine Protocols

Marc De Ley

editore: Humana Press Inc.

pagine: 256

During the last 30 years there has been a growing interest in cytokines as biological molecules able to regulate the most diverse functions in living org- isms, mainly at the level of cell-cell communication. Originally their definition was limited to the cells of the immune system (interleukins and lymphokines), but later that definition was extended to all cells, and their regulatory activity in such other processes as differentiation, apoptosis, angiogenesis, and wound he- ing has been now demonstrated. They comprise a group of small proteins (5-20 kDa) produced and released by cells in a tightly controlled fashion, active in the nano- or picomolar concentration range, and eliciting specific effects in nei- boring cells; therefore, their action is said to be autocrine, paracrine, or jux- crine. The latter property distinguishes them from hormones, which are produced by one tissue and are transported by the blood stream in order to act on a distant tissue. Chemokines are a subset of cytokines, but whether growth factors are included in the group is often a matter of discussion. The activity of several cytokines can be inhibited by other cytokines or by biological response modi- ers; therefore, the latter are sometimes called "anti-cytokines. " The biological response of a particular cell is usually the result of the sum of all interactions with cytokines present at a certain time and in a certain sequence in time-the "cytokine network.
131,00 111,35

Renal Disease

Techniques and Protocols

Michael S. Goligorsky

editore: Humana Press Inc.

pagine: 518

"Rule IV. There is need of a method for finding out the truth. Rule V. Method consists entirely in the order and disposition of the objects toward which our mental vision must be directed if we would find out any truth. We shall comply with it exactly if we reduce involved and obscure propositions step be step to those that are s- pler, and then starting with the intuitive apprehension of all those that are absolutely simple, attempt to ascend to the knowledge of all others by precisely similar steps. " -Rene Descartes, Rules for the Direction of Mind "...Perhaps he would sooner satisfy himself by resolving light into colours as far as may be done by Art, and then by examining the properties of those colours apart, and afterwards by trying the effects of reconjoyning two or more or all of those, and lastly by separating them again to examine what changes that reconjunction had wrought in them. This will prove a tedious and difficult task to do it as it ought to be done but I could not be satisfied till I had gone through it. " -From Newton's letter, quoted in The Life of Isaac Newton by Richard Westfall. Cambridge University Press, 1993.
171,00 145,35


A Practical Approach

Vladimir P. Torchilin, Volkmar Weissig

editore: Oxford University Press

pagine: 420

Since the first edition of "Liposomes - A Practical Approach" was published in 1990, liposome technology has become a highly successful and rapidly developing area of preclinical and clinical research. During the 1990's, a number of liposome-based drugs reached the market in the US and Europe and several new aspects of liposome research have been discovered. As a consequence there has been an explosion of new procedures and techniques in the field. Reflecting both the significant changes in the field and these discoveries, this new edition contains a combination of chapters from the 1st edition which have been significantly updated, and several additional chapters. Each chapter contains contributions from experts in the field, and the book as a whole encompasses all key areas of liposome technology. The first half of the text addresses a number of essential experimental protocols such as the preparation, characterization, and storage of liposomes.
74,00 62,90

Bioingegneria della postura

a cura di A. Cappello, A. Cappozzo

editore: Pàtron

pagine: 592

50,00 45,00

Protein sequencing protocols

Methods in molecular biology

Smith, B. J.

editore: Humana Press

pagine: 493

153,00 130,05

PCR Protocols

Methods in Molecular Biology vol.226

Bartlett, J. M. S. , Stirling. D.

editore: Humana Press

pagine: 544

107,00 90,95

PCR primer

A laboratory manual

Dieffenbach, C. W. , Dveksler, G. S.

editore: Cshl Press

pagine: 520

156,00 132,60

Cytokines and colony stimulating factors

Methods and protocols

Korholz, D. , Kiess, W.

editore: Humana Press

pagine: 478

175,00 148,75
53,00 45,05

Human Molecular Biology

An Introduction to the Molecular Basis of Health and Disease

Richard J. Epstein

editore: Cambridge University Press

pagine: 656

Human Molecular Biology is an introduction to the molecular basis of health and disease for the new generation of life scientists and medical students. By integrating cutting-edge molecular genetics and biochemistry with the latest clinical information, the book weaves a pattern which unifies biology with syndromes, genetic pathways with developmental phenotypes, and protein function with drug action. From the origins of life to the present day, a narrative is traced through the workings of genomes, cells and organ systems, culminating in linking of laboratory technologies to future research horizons. Lavishly illustrated throughout with two-colour diagrams and full colour clinical pictures, this text brings the complexities and breadth of human molecular biology clearly to life. This seamless account breaks through the boundaries between molecular biology and medicine, and leads the reader on to a new dimension where the biological basis of health and disease is inescapably molecular. Human Molecular Biology scooped both the Richard Asher prize for best new textbook and the overall 'Medical Book of the Year' in the Society of Authors and Royal Society of Medicine Medical Book Awards 2003.
45,00 38,25

Superantigen Protocols

Teresa Krakauer

editore: Humana Press Inc.

pagine: 271

Superantigen Protocols assembles experimental protocols that have proved useful for the study of superantigens. These techniques will allow researchers from various areas of cell biology, microbiology, immunology, biochemistry, and molecular biology to assess the physical characteristics and biological effects of well-known superantigens as well as of putative substances that might have superantigenic activities, and to explore therapies for superantig- induced effects. Microbial exotoxins have been studied for decades as virulence factors because of their pathogenic effects. The term "superantigen" was coined by Marrack and Kappler a decade ago for some of these molecules because of their potent T-cell stimulatory activities. In recent years, advances in mole- lar biology provide recombinant as well as natural superantigens in highly purified form for physical characterization. Superantigens are now used extensively as tools to study interactions between receptors on cells of the immune system as they bind to major histocompatibility complex class II m- ecules on antigen-presenting cells and V regions of T-cell receptors. The b- ? logical effects that result from these interactions are studied both in vitro and in vivo. The intent of this book is, therefore, to bring together up-to-date te- niques developed by experts in the field of biochemistry, immunology, and molecular biology for the study of superantigens. Superantigen Protocols begins with an overview of the field to provide background information on the various classes of superantigens and their str- ture.
123,00 104,55

Mhc Protocols

R. Vaughan, SH Powis

editore: Humana Press Inc.

pagine: 340

The aim of MHC Protocols is to document protocols that can be used for the analysis of genetic variation within the human major histocompatibility complex (MHC; HLA region). The human MHC encompasses approximately 4 million base pairs on the short arm of chromosome 6 at cytogenetic location 6p21. 3. The region is divided into three subregions. The telomeric class I region contains the genes that encode the HLA class I molecules HLA-A, -B, and -C. The centromeric class II region contains the genes encoding the HLA class II molecules HLA-DR, -DQ, and -DP. In between is the class III region, originally identified because it contains genes encoding components of the complement pathway. The entire human MHC has recently been sequenced (1) and each subregion is now known to contain many other genes, a number of which have immunological functions. The study of polymorphism within the MHC is well established, because the region contains the highly polymorphic HLA genes. HLA polymorphism has been used extensively in solid organ and bone marrow transplantation to match donors and recipients. As a result, large numbers of HLA alleles have been identified, a process that has been further driven by recent interest in HLA gene diversity in ethnic populations. The extreme genetic variation in HLA genes is believed to have been driven by the evolutionary response to infectious agents, but relatively few studies have analyzed associations between HLA genetic variation and infectious disease, which has been difficult to demonstrate.
148,00 125,80

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