Biological psychiatry has dominated psychiatric thinking for the past 40 years, but the knowledge base of the discipline has increased substantially more recently, particularly with advances in genetics and neuroimaging. The third edition of Biological Psychiatry has been thoroughly updated taking into account these developments. As in the earlier editions of the book, there are comprehensive reviews and explanations of the latest advances in neurochemistry, neuroanatomy, genetics and brain imaging- descriptions not only of methodologies but also of the application of these in clinical settings. It is within this context that there is a considerable emphasis in the book on brain-behaviour relationships both within and without the clinical setting. This edition has been enhanced by the inclusion of new chapters, one on anxiety and another on motivation and the addictions. The chapter that relates to treatments has been extended to include the latest information on brain stimulation techniques. The overall book is well illustrated in order to help with an understanding of the text.
For the third edition, Professor Michael Trimble has been joined by Professor Mark George as co-author. These are two of the world's leading biological psychiatrists who both have considerable clinical as well as research experience which they have brought to the book. Unlike multiauthored texts, it has a continuity running through it which aids understanding and prevents repetition. This book is strongly recommended for all practising psychiatrists and trainees wishing for an up-to-date, authoritative, easy to digest and acessible review of the latest advances and conceptualizations in the field. It will also appeal to neurologists interested in neuropsychiatry and biological psychiatry or the psychiatric aspects of neurological disorders, as well as other practising clinicians (psychologists, social workers, nurses) in the mental health field.
Acknowledgements. Quotations. Preface to the First Edition. Preface to the Second Edition. Introduction and Preface to the Third Edition. 1 Principles of Brain Function and Structure: 1 Genetics, Physiology and Chemistry. Introduction. Genetics. Brain chemistry and metabolism. The metabolism of glucose. Proteins and fatty acids. Cell membranes. Synapses. Receptors. Neurones. Neurotransmitters. Interrelationships among transmitters. Transmitter dispersal. CNS inflammation. 2 Principles of Brain Function and Structure: 2 Anatomy. Introduction. The neuroanatomy of emotion. Individual anatomical structures. Ascending and descending limbic-system connections. Macrosystems. The basal ganglia and the re-entrant circuits. The ventral striatum and 'limbic striatum'. The ascending cholinergic systems. Cortical regions of interest. The cerebellum. 3 Important Brain-Behaviour Relationships. Introduction. Important anatomical structures for understanding behaviour. Some specific behaviours. Limbic lobe disorders in a clinical context. Re-entrant circuits in a clinical context. The frontal lobes in a clinical context. Laterality. 4 Classifications and Clinical Investigations. Introduction. Signs, symptoms, syndromes and disease. Classification in psychiatry. Clinical investigation. 5 Personality Disorders. General introduction. Introduction to the concept of personality. Genetics. Somatic variables. Metabolic and biochemical findings. Neurophysiological and neurological data. Some outstanding issues. 6 Anxiety Disorders. Introduction. Genetics. Somatic variables. Metabolic and biochemical findings. Neurochemical investigations. Neurophysiological and neurological data. Imaging. Obsessive-compulsive disorder. Post-traumatic stress disorder. Some outstanding issues. 7 The Schizophrenias. Introduction. Genetics. Somatic variables. Metabolic and biochemical findings. Neurochemical investigations. Neurophysiological and neurological data. Some outstanding issues. 8 Affective Disorders. Introduction. Genetics. Metabolic and biochemical findings. Neurochemical investigations. Neurophysiological and neurological data. Some outstanding issues. 9 The Addictions and Disorders of Motivation. Introduction. Disorders of motivation. Conditioning. Genetics. Metabolic and biochemical findings. Neurophysiological and neurological data. Some outstanding issues. 10 Epilepsy. Introduction. Prevalence and clinical characteristics. Classification. Genetics. Symptomatic epilepsy. Biochemical findings. Investigation and differential diagnosis. Psychiatric disorders in epilepsy. Cognitive deterioration and epilepsy. Some outstanding issues. 11 The Dementias. Introduction. Definition. Prevalence. Diagnosis and classification. Alzheimer's disease. Dementia of frontal-lobe type. Focal cortical atrophies. Dementia with Lewy bodies. Vascular dementias. Other forms of dementia. Further causes of dementia. Some outstanding issues. 12 Biological Treatments. Introduction. Pharmacology: pharmacokinetics and pharmacodynamics. Antidepressants. Antipsychotic drugs. Anxiolytics and hypnotics. Beta-Adrenergic blockers. Lithium. Anticonvulsants. Drugs for the treatment of dementia. Medications for the addictions. Brain-stimulation therapies. Sleep-deprivation therapy. 13 Epilogue: Progress toward a Neuroanatomically, Biological-psychiatrically Informed Classification Scheme in Psychiatry. References. Index.