This volume reviews comprehensively the present understanding of the clinical pharmacology and therapeutics of currently available antihypertensive agents. As fewer new molecules are entering development, it becomes increasingly important to utilise existing drugs in a way that exploits their full potential through a greater understanding of their molecular biology and pharmacogenomics.
Haemodynamic effects. Angiotensin converting enzyme inhibitors. Pharmacokinetics, pharmacodynamics, metabolism, side effects and drug interactions. Alpha-blocking drugs. Calcium channel blockers. Angiotensin receptor blockers. Interaction of antihypertensive drugs with mechanisms of blood pressure regulation. Methyldopa and imidazoline agonists. The evidence base for treatment. Combination therapy. Elderly. Vasopeptidase inhibitors. Ethnic Groups.