Thoroughly updated for its Sixth Edition, "Principles and Practice of Pediatric Oncology" provides a comprehensive review of the multiple disciplines that make up the care and research agendas for children with cancer. It is the most comprehensive textbook of pediatric oncology ever put together, covering biology and genetics and detailing the diagnosis, multimodal treatment, and long-term management of patients with cancer. The fundamental principles of supportive care and the psychosocial aspects of support for patients and families are also discussed. Twenty per cent of the chapters in this edition are either brand-new or written by new contributors, and all the other chapters have been considerably updated. The book provides state-of-the-art information on the molecular genetics and biology of cancer as well as new approaches to diagnosis and management. A companion website offers the fully searchable text.
xvi Preface xvii Chapter 1 Epidemiology of Childhood Cancer 2 Michael E. Scheurer, Melissa L. Bondy, and James G. Gurney Chapter 2 Childhood Cancer and Heredity 17 Sharon E. Plon and David Malkin Chapter 3 Molecular and Genetic Basis of Childhood Cancer 38 Peter D. Aplan and Javed Khan Chapter 4 Biology of Childhood Cancer 78 Christopher Denny and Kathleen Sakamoto Chapter 5 Tumor Immunology and Pediatric Cancer 97 Crystal L. Mackall and Paul M. Sondel BIOLOGICAL BASIS OF CHILDHOOD CANCER Chapter 6 Clinical Assessment and Differential Diagnosis of the Child with Suspected Cancer 123 Lindsay B. Kilburn, Marcio H. Malogolowkin, John J. Quinn, Stuart E. Siegel, and C. Philip Steuber Chapter 7 Pathology and Molecular Diagnosis of Leukemias and Lymphomas 138 Amy Heerema-McKenney, Michael L. Cleary, and Daniel A. Arber Chapter 8 Diagnostic Pathology of Pediatric Malignancies 164 Timothy J. Triche, John Hicks, and Poul H.B. Sorensen Chapter 9 Imaging Studies in the Diagnosis and Management of Pediatric Malignancies 216 R. Paul Guillerman, Mary E. (Beth) McCarville, Sue C. Kaste, Barry L. Shulkin, and Stephan D. VossOF MULTIMODAL THERAPY Chapter 10 General Principles of Chemotherapy 279 Peter C. Adamson, Rochelle Bagatell, Frank M. Balis, and Susan M. Blaney Chapter 11 Molecularly Targeted Therapies and Biotherapeutics 356 Malcolm A. Smith Chapter 12 General Principles of Surgery 386 Christopher B. Weldon, Tom Jaksic, and Robert C. Shamberger Chapter 13 General Principles of Radiation Oncology 406 Larry E. Kun Chapter 14 Cell and Gene Therapies 426 Stephen Gottschalk, Cliona M. Rooney, and Malcolm K. Brenner Chapter 15 Infants and Adolescents with Cancer: Special Considerations 446 Zoann Dreyer, Daniel J. Indelicato, Gregory H. Reaman, and W. Archie Bleyer Chapter 16 Hematopoietic Stem Cell Transplantation in Pediatric Oncology 467 Catherine M. Bollard, Robert A. Krance, and Helen E. Heslop Chapter 17 Cancer Clinical Trials: Design, Conduct, Analysis, and Reporting 491 Susan Hilsenbeck, Lisa R. Bomgaars, and Stacey L. Berg Chapter 18 Regulating Patient Safety in Cancer Treatment 508 Brigitta U. Mueller and Amy L. Billett Chapter 19 Acute Lymphoblastic Leukemia 518 Judith F. Margolin, Karen R. Rabin, C. Philip Steuber, and David G. Poplack Chapter 20 Acute Myeloid Leukemia, Myeloproliferative and Myelodysplastic Disorders 566 Todd M. Cooper, Henrik Hasle, and Franklin O. Smith Chapter 21 Chronic Leukemias of Childhood 611 Arnold J. Altman and Cecilia Fu Chapter 22 Hodgkin Lymphoma 638 Monika Metzger, Matthew J. Krasin, Melissa M. Hudson, and Mihaela Onciu Chapter 23 Malignant Non-Hodgkin Lymphomas in Children 663 Thomas G. Gross and Sherrie L. Perkins Chapter 24 Lymphoproliferative Disorders and Malignancies Related To Immunodeficiencies 683 Bruce Shiramizu, Robert Wilkinson, and Robert Hayashi Chapter 25 Histiocytic Diseases 703 Kenneth L. McClain, Carl E. Allen, and John Hicks Chapter 26 Tumors of the Central Nervous System 717 Chapter 26A Gliomas, Ependymomas, and Other Nonembryonal Tumors 717 Susan M. Blaney, Daphne Haas-Kogan, Tina Young Poussaint, Mariarita Santi, Richard Gilbertson, Donald "Will" Parsons, and Ian PollackF COMMON CANCERS OF Chapter 26B Embryonal and Pineal Region Tumors 772 Roger J. Packer, Lucy B. Rorke-Adams, Ching C. Lau, Michael D. Taylor, Gilbert Vezina, and Larry E. Kun Chapter 27 Retinoblastoma 809 Richard L. Hurwitz, Carol L. Shields, Jerry A. Shields, Patricia Chevez-Barrios, Dan Gombos, Mary Y. Hurwitz, and Murali M. Chintagumpala Chapter 28 Pediatric Liver Tumors 838 Rebecka L. Meyers, Daniel C. Aronson, Dietrich Von Schweinitz, Arthur Zimmermann, Marcio H. Malogolowkin Chapter 29 Renal Tumors 861 Conrad Fernandez, James I. Geller, Peter F. Ehrlich, D. Ashley Hill, John A. Kalapurakal, Paul E. Grundy, and Jeffrey S. Dome Chapter 30 Neuroblastoma 886 Garrett M. Brodeur, Michael D. Hogarty, Yael P. Mosse, and John M. Maris Chapter 31 Rhabdomyosarcoma 923 Leonard H. Wexler, William H. Meyer, and Lee J. Helman Chapter 32 The Nonrhabdomyosarcoma Soft Tissue Sarcomas 954 M. Fatih Okcu, Alberto S. Pappo, John Hicks, Lynn Million, Richard J. Andrassy, and Sheri L. Spunt Chapter 33 Ewing Sarcoma 987 Douglas S. Hawkins, Tobias Bolling, Steven Dubois, Pancras C.W. Hogendoorn, Heribert Jurgens, Michael Paulussen, R. Lor Randall, and Stephen L. Lessnick Chapter 34 Osteosarcoma: Biology, Diagnosis, Treatment, and Remaining Challenges 1015 Richard Gorlick, Stefan Bielack, Lisa Teot, James Meyer, R. Lor Randall, and Neyssa Marina Chapter 35 Germ Cell Tumors 1045 Thomas A. Olson, Dominik T. Schneider, and Elizabeth J. Perlman Chapter 36 Endocrine Tumors 1068 Steven G. Waguespack, Andrew J. Bauer, Winston Huh, and Anita K. Ying Chapter 37 Management of Infrequent Cancers of Childhood 1098 Alberto S. Pappo, Carlos Rodriguez-Galindo, and Wayne L. Furman Chapter 38 Oncologic Emergencies 1125 Michael J. Fisher and Susan R. Rheingold Chapter 39 Hematologic Supportive Care for Children with Cancer 1152 Anurag K. Agrawal, Caroline A. Hastings, and James Feusner Chapter 40 Infectious Complications in Pediatric Cancer Patients 1190 Andrew Y. Koh and Philip A. Pizzo Chapter 41 Nutritional Supportive Care 1243 Sonia Arora Ballal, Lori J. Bechard, Tom Jaksic, and Christopher Duggan Chapter 42 Pain and Symptom Management 1256 Elliot J. Krane, Jacqueline Casillas, and Lonnie K. Zeltzer Chapter 43 Nursing Support of the Child with Cancer 1288 Marilyn J. Hockenberry and Nancy E. Kline Chapter 44 Rehabilitation of the Child with Cancer 1305 David W. Pruitt, Mary A. McMahon, Stephanie R. Ried, Susan D. Apkon, and Linda J. Michaud Chapter 45 Psychiatric and Psychosocial Support for the Child and Family 1322 Lori S. Wiener, Stephen P. Hersh, and Melissa A. Alderfer Chapter 46 Ethical Considerations in Pediatric Oncology 1347 Steven Joffe, Jennifer Kesselheim, and Susan B. Shurin Chapter 47 Late Effects of Childhood Cancer and Its Treatment 1368 Saro H. Armenian, Anna T. Meadows and Smita Bhatia Chapter 48 Educational Issues for Children with Cancer 1388 Laurie D. Leigh and Heather M. Conklin Chapter 49 Palliative Care for the Child with Cancer 1404 Christina Ullrich, Barbara Sourkes, and Joanne Wolfe Chapter 50 Economic Issues in Pediatric Cancer 1428 Susan K. Parsons, Joshua T. Cohen, and Melissa L. Lichte Chapter 51 Pediatric Cancer: Advocacy, Insurance, Education, and Employment 1441 Susan L. Weiner, Gilbert P. Smith, Grace P. Monaco, and Joseph Fay Chapter 52 Complementary and Alternative Medical Therapies in Pediatric Oncology 1451 Thomas W. McLean and Kathi J. Kemper Chapter 53 Pediatric Oncology in Countries with Limited Resources 1463 Ronald Barr, Federico Antillon, Bharat Agarwal, Parth Mehta, and Raul Ribeiro Chapter 54 Preventing Cancer in Adulthood: Advice for the Pediatrician 1474 Brad H. Pollock and Gail E. Tomlinson Chapter 55 Resources for Children with Cancer, their Families, and Physicians 1489 Cheryl C. Rodgers Index 1509