This new companion to "Hochberg et al.'s Rheumatology" masterwork provides new insights into the causes, detection and therapy of this challenging disease. In this state-of-the-art resource, you'll find 'one stop' coverage of all the latest scientific and clinical developments in SLE: new concepts in epidemiology, disease activity measures and outcomes; new concepts in immunoregulation, genetic and pathogenic mechanisms; new understanding and novel presentation of the processes of tissue/organ damage; comprehensive coverage of clinical features; and the very latest concepts in treatment.
Epidemiology and Diagnosis 1. Epidemiology 2. Disease Activity Measures 3. Disease Outcome 4. Quality of Life and Economic Aspects Pathogenesis 1. Overview of the Pathogenesis of SLE 2. Genetics 3. Hormones 4. Immunoregulation - T Cells, B cells, and cytokines. 5. Cell Surface Receptors ostimulation/BAFF/FcgR/TLRs) 6. Dendritic Cells 7. Apoptosis 8. Structure and Origin of Autoantibodies 9. Animal Models 10. Genetics of murine lupus 11. Infection and autoimmunity Mechanisms of Tissue Damage 1. Complement 2. Immune complexes 3. Antibodies a. ANA and standardization of antibody techniques b. Anti-DNA c. Anti-splicesomosal ab d. Anti-Ro/La e. Anti-Histone f. APL g. Anti-neuronal 4. PMNs 5. Mechanisms of renal damage 6. Mechanisms of vascular damage 7. Nitric Oxide Clinical Aspects of the Disease 1. Constitutional Symptoms and Fatigue 2. Skin 3. Kidney 4. Heart 5. Lung 6. GI/liver/pancreas 7. Infections 8. Blood (anti-phospholipid syndrome) 9. Nervous System 10. Overlap Syndromes 11. Ophthalmic Manifestations 12. Pregnancy 13. Fertility 14. Neo-natal lupus 15. Hereditary and Malignant Lupus-like Diseases Treatment of the Disease 1. Non-Steroidals - Anti-Malarials and Statins 2. Steroid Treatment 3. Cytotoxic Drug Treatment including M.M.F 4. PAPS 5. New Treatments