This book considers the relationship between obstructive sleep apnea (OSA) and cardiovascular disease, right and left ventricular dysfunction, and hypertension. It analyses techniques to identify, diagnose, and monitor sleep-induced upper airway obstruction; developments in functional brain imaging associated with sleep and sleep deprivation advances in oral appliance and continuous positive airway pressure (CPAP) therapies and explores breakthroughs in the establishment of genetic, environmental, and developmental factors of OSA; the significance of cytokines in sleep regulation; and; the effect of sleep on ventilatory control. Summarizing landmark studies in the field and providing more than 2000 contemporary references to facilitate further scientific investigation, "Sleep Apnea" is an in-depth guide for pulmonologists; physiologists; chest, pulmonary, thoracic, and cardiovascular physicians and surgeons; cardiologists; respiratory therapists; clinical neurologists; sleep disorder specialists; and upper-level undergraduate, graduate, and medical school students in these disciplines.
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Anatomical Factors: Insights from Imaging StudiesRichard J. Schwab and Warren B. GefterBiomechanics of the Upper Airway During SleepPhilip L. Smith and Alan R. SchwartzSleep-Induced Respiratory InstabilitiesJerome A. Dempsey, Curtis A. Smith, Christine R. Wilson, Peter R. Eastwood, Michael C. K. CohoMechanisms of Airway HypotoniaLeszek Kubin and Richard O. DaviesAirway Reflexes: Changes with SleepDavid P. WhiteArousal Mechanisms and Autonomic ConsequencesRichard L. HornerMuscle Factors in Obstructive Sleep ApneaBasil J. Petrof and Joan C. HendricksThe Genetics of the Obstructive Sleep Apnea Hypopnea SyndromeSusan Redline, Peter V. Tischler, and Kingman P. StrohlMechanisms of Sleepiness in Obstructive Sleep ApneaDeepak K. Chugh and David F. DingesFunctional Brain Imaging During Sleep and Sleep Deprivation in Health and Disease